电子止吐仪联合托烷司琼防治顺铂化疗所致呕吐的疗效观察

目的:观察电子止吐仪联合托烷司琼预防顺铂化疗所致呕吐的疗效。方法:采用随机、自身交叉对照的方法，将120例接受两周期含顺铂联合化疗的患者，随机分为AB组60例、BA组60例。AB组第1周期应用电子止吐仪联合托烷司琼止吐，第2周期单用托烷司琼止吐；BA组第1周期单用托烷司琼止吐，第2周期应用电子止吐仪联合托烷司琼止吐。观察和记录两组患者化疗后恶心、呕吐的控制情况。结果:AB组化疗第1周期（A方案）和第2周期（B方案）恶心的有效控制率分别为93.1%、79.3%，呕吐有效控制率分别为86.2%、70.7%，差异有统计学意义(P<0.05)；BA组化疗第1周期（B方案）和第2周期（A方案）恶心的有效控制率分别为71.7%、93.3%，呕吐有效控制率分别为70.0%、86.7%，差异有统计学意义(P<0.05)。两种方案的主要不良反应为头痛、眩晕、腹泻、便秘、心悸、口干等，不良反应发生率比较差异无统计学意义（P>0.05）。结论:电子止吐仪联合托烷司琼预防顺铂化疗所致呕吐优于单用托烷司琼，不良反应可以耐受，可作为防治顺铂化疗所致呕吐的常规措施。

Clinical observation of electronic antiemetic acupuncture combined with tropisetron in the prevention of vomiting induced by cisplatin chemotherapy

Objective:To observe clinical efficacy and ADR of electronic antiemetic acupuncture combined with tropisetron in the prevention of vomiting induced by cisplatin chemotherapy.Methods:Randomized self-cross controlled method was applied.All 120 patients received two courses of cisplatin based chemotherapy were randomized into group AB and BA.Group AB received electronic antiemetic acupuncture combined with tropisetron in the first cycle while tropisetron alone in the second cycle.Group BA was given tropisetron alone in the first cycle while electronic antiemetic acupuncture combined with tropisetron in the second cycle.Observe and record two groups patients after chemotherapy control nausea and vomiting.Results:Rate of improvement of nausea for the AB group of the first cycle（A） and the second cycle(B） were 93.1% vs 79.3%.Response rate of prevention of vomit for the AB group of the first cycle（A） and the second cycle(B） were 86.2% vs 70.7%(P<0.05).Response rate of improvement of nausea for the BA group of the first cycle（B） and the second cycle(A） were 71.7% vs 93.3%.Response rate of prevention of vomit for the BA group of the first cycle（B） and the second cycle(A） were 70.0% vs 86.7%(P<0.05).The most common ADR in both regimens were headache，dizziness，diarrhea，constipation，heart palpitations,mouth dry.There was no statistical significance in the incidence of ADR（P>0.05）.Conclusion:The treatment of electronic antiemetic acupuncture in combination with tropisetron on had greater effect in prevention of vomiting induced by cisplatin chemotherapy，with tolerable toxcity profile.It can be used conventionally in the chemotherapy.