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| 基质金属蛋白酶与慢性阻塞性肺疾病关系的研究进展 | |
| 引用本文： | 王元元,李建生. 基质金属蛋白酶与慢性阻塞性肺疾病关系的研究进展[J]. 河南中医药学刊, 2011, 0(4): 401-403 |
| 作者姓名： | 王元元 李建生 |
| 作者单位： | [1]河南中医学院第一附属医院呼吸内科,河南郑州450000 [2]河南中医学院老年医学研究所,河南郑州450008 |
| 基金项目： | 基金项目：国家自然科学基金（编号：30973743）;2010年度河南省科技创新人才项目（编号：104200510004） |
| 摘 要： | 目的：探讨基质金属蛋白酶与慢性阻塞性肺疾病的研究进展。方法：收集近年来国内外关于基质金属蛋白酶与慢性阻塞性肺疾病的相关研究进行归纳和分析。结果：基质金属蛋白酶参与慢性阻塞性肺疾病的发病,其特异性抑制剂将来可能在慢性阻塞性肺疾病的干预治疗中发挥重要作用。结论：基质金属蛋白酶与慢性阻塞性肺疾病的研究有待进一步深入。 |
| 关 键 词： | 慢性阻塞性肺疾病 基质金属蛋白酶 组织型金属蛋白酶抑制物 基因多态性 |
Study Progress of the Relationship Between Matrix MetaUoproteinases and Chronic Obstructive Pulmonary Disease |
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| Wang Yuan-yuan Li Jian-sheng. Study Progress of the Relationship Between Matrix MetaUoproteinases and Chronic Obstructive Pulmonary Disease[J]. Journal of Henan college of Traditional Chinese Medicine, 2011, 0(4): 401-403 | |
| Authors: | Wang Yuan-yuan Li Jian-sheng |
| Affiliation: | Wang Yuan-yuan Li Jian-sheng( The Respiratory Department of the First Affiliated Hospital of Henan University of TCM,Zhengzhou,Henan,China 450000 The Geriatricians Institute of the First Affiliated Hospital of Henan University of TCM,Zhengzhou,Henan,China 450008) |
| Abstract: | Objective ：To study the progress of matrix metalloproteinase with chronic obstructive pulmonary disease. Method ： Generalize and analyze the recently published studies on correlation between MMPs and COPD. Results：MMPs partleipate in the pathogenesis of COPD, the specific inhibitor of MMPs play an important role in the interference and treatment of COPD. Conclusion：The relationship between MMPs and COPD should be further studied. |
| Keywords: | Chronic Obstructive Pulmonary Disease matrix metallo - proteinases tissue inhibitor of metalloproteases gene polymor- phism |
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