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| HPLC法测定沙利度胺片中沙利度胺的含量 | |
| 引用本文： | 邱娟. HPLC法测定沙利度胺片中沙利度胺的含量[J]. 天津药学, 2011, 23(3): 16-17 |
| 作者姓名： | 邱娟 |
| 作者单位： | 广州市药品检验所,广州,510160 |
| 摘 要： | 目的：建立沙利度胺含量的质量控制方法。方法：采用Waters Nova-Pak C18柱（150 mm×3.9 mm,4μm）,以水-乙腈-磷酸（85∶15∶0.1）为流动相,流速为2 ml/min,检测波长为237 nm。结果：对照品在10.055～150.825μg/ml范围内呈良好线性关系（r=1.000）,回收率平均为100.7%,RSD为0.3%。结论：HPLC法准确、灵敏、可靠,专属性强,可用于测定沙利度胺片中沙利度胺的含量。 |
| 关 键 词： | 沙利度胺 含量测定 高效液相色谱法 |
Determination of contents of thalidomide tablets by HPLC |
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| Qiu Juan. Determination of contents of thalidomide tablets by HPLC[J]. Tianjin Pharmacy, 2011, 23(3): 16-17 | |
| Authors: | Qiu Juan |
| Affiliation: | Qiu Juan(Guangzhou Institute For Drug Control,Guangzhou 510160) |
| Abstract: | Objective: To establish a method for determining the content of thalidomide tablets.Methods: The HPLC method was performed on a Waters Nova-Pak C18 column(150 mm×3.9 mm,4 μm).The mobile phase was composed of water-acetonitrile-phosphoric acid(85∶15∶0.1) with UV detection at 237 nm and flow rate was 1.0 ml/min.Results: A good linearity was obtained over 10.055~150.825 μg/ml of thalidomide with a good correlation coefficient.Conclusion: This method was rapid,sensitive and accurate for the content determination of thalidomide tablets. |
| Keywords: | thalidomide tablets content determination HPLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |