基于Monaco的食管癌容积旋转调强计划中两种优化模式的剂量学比较

目的:对比Monaco治疗计划系统中Pareto和Constrained两种优化模式在食管癌容积旋转调强（VMAT）中的剂量学差异。 方法:回顾分析23例食管癌患者临床资料，使用Monaco治疗计划系统在相同优化条件下分别使用Pareto和Constrained模式进行优化和剂量评估。比较两种优化模式的靶区剂量、适形度指数、均匀性指数、危及器官受量、子野数和机器跳数。 结果:两种模式优化的靶区剂量、适形度指数、均匀性指数和危及器官受量差异不明显，无显著统计学意义（P>0.05）。 结论:在使用Monaco设计食管癌的VMAT治疗计划时使用Pareto和Constrained优化模式均可获得较好的剂量分布，可以应用于临床。

Comparison of dose distributions calculated by two optimization methods of Monaco system used in volumetric modulated arc therapy of esophageal cancer

Objective To compare the dosimetric differences in volumetric modulated arc therapy (VMAT) of esophageal cancer after Pareto optimization or Constrained optimization of Monaco treatment planning system. Methods The clinical information of 23 patients with esophageal cancer was retrospectively analyzed. With the same optimization parameters, the Pareto and Constrained optimization models of Monaco treatment planning system were used to optimize VMAT plans and perform dose verification. After optimization, the differences in target dose, conformity index, homogeneity index, organs-at-risk dose, segments and monitor units were compared. Results The differences between two optimized plans in the target dose, conformity index, homogeneity index, and organs-at-risk dose were trivial, without statistical significance (P>0.05). Conclusion Both Pareto and Constrained optimization models of Monaco treatment planning system for the optimization of VMAT plan of esophageal cancer can achieve a good dose distribution and is clinically applicable.