硅对尿石形成作用的探讨

本文采用原子吸收光谱仪精确测定31例尿石病人和20例正常人的血清和24小时尿硅值、24例结石的硅含量,用扫描电镜配合X线能谱仪观察和分析结石中含硅物质的形貌和元素成份。发现尿石病人血清和尿硅含量明显高于正常人(P值分别<0.05,<0.01)。结石普遍含有硅元素,平均含量0.20%,分布均匀,主要呈长方形和多边形的纯硅晶体或不规则和无定形的含硅混合物。推测硅参与尿石的形成。

An Approach to the Effect of Silicon on the Formation of Urinary Calculi

The concentrations of silicon in 29 serum, 31 urine and 24 stone samples from 31 palients with urinary calculi, and 20 serum and 20 urine samples from 20 healthy controls were determined by atomic absorption spectropho.ometry using the carbon (flamelcss) furnace. The structure and composition of silica in 24 stones from patients were studied by scanning electron microscope fitted up with an energy dispersive microanalyzer. The results showed that silicon concentrations of serum and 24 hours urine of patients are significantly higher than that of healthy controls (P<0.05 and P<0.01 respectively). The level of silicon in urinary calculi averages 0.20%. The distribution of silicon in these stones is balanced.The forms in which silica could be found in stones are rectangular and multilateral pure silica crystalline or amorphous form containing other elements such as Ca, P, K, A1, K, S, C1, Mg, Na, and Fe. We supsected that silicon took part in the formation of urinary calauli. We also discussed the mechanism of stone formation and the methods of prevention and treatment for urinary calculi.