| 阿霉素对小鼠心肌过氧化代谢的影响 |
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| 引用本文： | 程听,徐光禄. 阿霉素对小鼠心肌过氧化代谢的影响[J]. 中国药理学通报, 1989, 0(4) |
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| 作者姓名： | 程听 徐光禄 |
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| 作者单位： | [1]西安医科大学克山病研究室 [2]西安医科大学克山病研究室 安徽医科大学生化教研室 |
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| 摘 要： | 抗肿瘤药物阿霉素可引起明显的心肌毒性。阿霉素(17.5mg/kg ip)所致小白鼠亚急性中毒时,可引起心肌过氧化代谢异常,包括TBA值升高和谷胱甘肽过氧化物酶活性的降低,并且这二者之间不互成因果关系;同时心肌也可出现早期病理变化——D-PAS较强阳性。这种早期病理变化的出现可能与过氧化代谢产物积蓄性升高有关。
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| 关 键 词： | 阿霉素 小白鼠 心肌 过氧化代谢 |
EFFECT OF ADRIAMYCIN ON HEART PEROXIDATION IN MICE |
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| Abstract: | In mice, adriamycin (l7.5mg/kg, ip ) produced heart peroxida-tion abnormality including increased TBA value & decreased gluta-thione peroxidase activity, respectively. But the change of former was not parallel to the latter. The drug also produced early pathological change of the heart i.e. more D-PAS positiveness. The results suggested that the early heart pathological change produced by adriamycin may be related to increased accumulation of pero-xi dative products. |
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| Keywords: | Adriamycin Mice Heart Petoxidation |
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