不同剂量瑞舒伐他汀钙治疗老年冠心病合并高脂血症的疗效及安全性对比分析

目的 对比不同剂量瑞舒伐他汀钙治疗老年冠心病合并高脂血症的疗效及安全性.方法 选择我院120例老年冠心病合并高脂血症患者,随机分为5 mg组、10 mg组和20 mg组,每组40例,3组患者均于每晚餐后顿服瑞舒伐他汀钙片(可定),剂量分别为5 mg、10 mg和20 mg,疗程均为16周.16周后观察3组患者的降脂疗效及安全性.结果 各组患者TC、TG和LDL-C水平均明显降低,但20 mg组的TC、TG、LDL-C水平降低较其他两组明显(P<0.05).5 mg组中显效14例,有效16例,无效9例,恶化1例;10 mg组中显效18例,有效14例,无效7例,恶化1例;20 mg组中显效24例,有效13例,无效3例,恶化0例,3组疗效比较差异有统计学意义(Hc=6.522,P<0.05).瑞舒伐他汀钙20 mg组的疗效优于10 mg组和5 mg组,差异有统计学意义(P<0.05).5 mg组、10 mg组、20 mg组胆固醇达标率分别为60.0%(24/40)、70.0%(28/40)和87.5%(35/40),3组比较差异有统计学意义(χ2=7.77,P<0.05).结论 大剂量瑞舒伐他汀钙治疗老年冠心病合并高脂血症的疗效显著,且安全性好,值得临床推广.

Efficacy and Safety of Rosuvastatin Calcium in Treatment of Elderly CHD Patients with Hyperlipidemia

Objective To observe the efficacy and safety of rosuvastatin calcium in treatment of elderly patients with coronary heart disease (CHD) complicated by hyperlipidemia.Methods One hundred twenty elderly CHD patients with hyperlipidemia were randomized into groups 5 mg,10 mg,20 mg,40 in each.All were given rosuvastatin calcium immediately after dinner,in doses of 5 mg,10 mg,20 mg,respectively,16 weeks.The lipid-lowering efficacy and safety were observed after 16 weeks.Results The levels of TC,TG,LDL-C decrease...