Pharmacokinetics of high doses of piretanide in moderate to severe renal failure |
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Authors: | C Marone F C Reubi M Perisic W Lahn |
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Institution: | (1) Medizinische Poliklinik, Universität Bern, Switzerland;(2) Ospedale San Giovanni, Bellinzona, Switzerland;(3) Hoechst Pharma AG, Zürich, Switzerland;(4) Department for Clinical Research, Hoechst AG, Frankfurt/Main, Federal Republic of Germany |
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Abstract: | Summary The pharmacokinetics of piretanide was studied in 10 patients with chronic renal failure. After administration of a high oral dose (12 to 192 mg) of piretanide the kinetics behaved according to an open 2-compartment model. The elimination constant in the first phase () ranged from 0.385 to 0.756 h–1 and in the second phase () from 0.079 to 0.274 h–1. The corresponding elimination half-lives ranged from 55 to 108 min (t1/2 ) and from 152 to 524 min (t1/2
). Only an average of 2.8% of the orally administered drug was recovered in 24 h urines. Nevertheless, a good correlation was found between urinary recovery or renal clearance of the drug and residual renal function. The elimination of piretanide by non-renal mechanisms appeared to be increased when renal function was greatly diminished. |
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Keywords: | piretanide renal insufficiency furosemide pharmacokinetics loop diuretic |
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