大鼠异位辅助性肝移植模型建立

目的 建立大鼠异位辅助性肝移植模型。方法 根据Yu Weiming介绍的方法经以简化建立大鼠异位辅助性肝移植模型。阐明手术操作技巧和术前术后处理等因素对肝移植大鼠的成活率的影响。结果 在30例异位辅助性肝移植大鼠中，供肝热缺血时间为1-2min，安装袖套时间约为4min，肝下腔静脉吻合时间为12min，供肝冷缺血时间为30min,1wk存活率为80%（n=30)。结论 成功复制大鼠辅助性肝移植模型。同时，大鼠的质量，术前状态和精细的手术操作及管理是决定大鼠异位辅助性肝移植成败的关键因素。

A Simplified Method to establish heterotopic auxiliary liver transplantation in rat

AIM To investigate the perioperation treatment in rat heterotopic liver transplantation. METHODS By using the Yu's method to establish the model of rat auxiliary liver transplantation and to observe the effects of such factors as recipient rat status, surgical techniques, pre and postoperative managements on the survival rate of rat transplantation. RESULTS Of the 30 cases of heterotopic liver transplantation in our study, the 1 week survival rate was 80%. CONCLUSION The model of auxiliary heterotopic liver transplantation in rats has been successfully duplicated. The rat weight, strain, gender, preoperative status, elaborate surgical manipulation and managements are the vital factors in the success of rat liver transplantation.