血栓通治疗不稳定型心绞痛的临床疗效研究

目的研究血栓通治疗不稳定型心绞痛(UAP)的临床疗效。方法选择2011年3月—2013年3月在延安大学咸阳医院心内科住院治疗的UAP患者60例,随机分为血栓通组和对照组,各30例。对照组予以常规药物治疗,血栓通组在对照组治疗基础上加用血栓通治疗,均观察14 d。比较两组患者治疗前后心绞痛发作频率和持续时间,记录两组患者心电图ST段压低≥0.25 m V的导联总数(NST)和心电图ST段压低的电压总量(∑ST),判定两组患者心绞痛症状疗效和心电图疗效,观察两组患者临床终点事件和不良反应发生情况。结果治疗前两组患者心绞痛发作频率和持续时间比较,差异无统计学意义(P0.05);治疗后血栓通组患者心绞痛发作频率少于对照组〔(1.4±1.3)次∕周比(2.2±1.4)次/周,P0.05〕,持续时间短于对照组〔(3.3±1.8)min/次比(4.3±1.9)min∕次,P0.05〕,心电图NST少于对照组〔(1.14±1.04)个比(1.70±1.06)个,P0.05〕、心电图∑ST低于对照组〔(2.64±1.13)mm比(3.42±1.34)mm,P0.05〕。血栓通组患者心绞痛症状总有效率为90.0%,高于对照组的70.0%(P0.05);血栓通组患者心电图总有效率为86.7%,高于对照组的66.7%(P0.05)。对照组患者临床终点事件发生率为13.3%,与血栓通组的6.7%比较,差异无统计学意义(P0.05)。治疗期间两组患者均未出现过敏反应、严重出血。结论在常规药物治疗基础上应用血栓通治疗UAP安全有效,能进一步改善患者心绞痛症状和心电图表现。

Clinical Effect of Xueshuantong on Unstable Angina Pectoris

Objective To study the clinical effect of xueshuantong on unstable angina pectoris（UAP）. Methods A total of 60 UAP patients admitted to Department of Cardiology,Xianyang Hospital of Yan＆#39;an University were selected and random- ly divided into xueshuantong group（n ﹦ 30） and control group（n ﹦ 30）. Control group given conventional drug treatment, while xueshuantong group given extra xueshuantong on the basis of control group. Both groups treated for 14 days. Angina attack frequency and duration before and after treatment between the two groups were compared,total of lower ST segment leads（≥0. 25 mV）of ECG（NST）,total voltage of lower ST segment（∑ST）were recorded,angina pectoris symptom effect and ECG effect were judged,incidence of clinical endpoint events and adverse reactions were observed. Results There was no significant differences of angina attack frequency and duration,NST and ∑ST before treatment between the two groups（P 〉 0. 05）;after treatment,angina attack frequency of xueshuantong group〔（1. 4 ± 1. 3） times per week〕 was less than that of control group〔（2. 2 ± 1. 4）times per week〕（P 〈 0. 05）,the angina attack duration of xueshuantong group〔（3. 3 ± 1. 8）min per time〕was shorter than that of control group〔（4. 3 ± 1. 9） min per time〕（P 〈 0. 05）,the NST of xueshuantong group（1. 14 ± 1. 04）was less than that of control group（1. 70 ± 1. 06）（P 〈 0. 05）,the ∑ST of xueshuantong group〔（2. 64 ± 1. 13）mm〕was lower than that of control group〔（3. 42 ± 1. 34）mm〕（P 〈 0. 05）. The total angina pectoris symptom effective rate of xue- shuantong group was 90. 0% ,was higher than that of control group of 70. 0% （P 〈 0. 05）;the total ECG effective rate of xue- shuantong group was 86. 7% ,was higher than that of control group of 66. 7% （P 〈 0. 05）. The incidence of clinical endpoint e- vents of xueshuantong group was 6. 7% ,that of control group was 13. 3% ,the difference was not signi