复方红景天对重症肺动脉高压体外循环肺损伤的防治作用

目的：探讨复方红景天对重症肺动脉高压体外循环急性肺损伤早期防治的可能性。方法：根据彩超筛选出76例重症肺动脉高压患者，随机分为治疗组与对照组。两组一般处理相同，包括术前准备、手术操作及常规用药。治疗组则在术前口服7～10天，术后口服5～7天复方红景天，4g／d，儿童用量减半。两组按规定时间点进行生命体征、肺通气参数、动脉血气分析、血栓烷族系的检测。结果：治疗组多项指标均优于对照组(P<0．05或P<0．01)。急性肺损伤发生率和因肺损伤死亡者治疗组分别为7．5％(3／40)、0(0／3)；对照组为19．4％(7／36)、43％(3／7)。结论：复方红景天对体外循环手术并发急性肺损伤有较好的防治作用。

Preventive and Treatment Effect of Composite Rhodiolae on Acute Lung In jury in Patients with Severe Pulmonary Hypertension during Extracorporeal Circulation

OBJECTIVE: To investigate the possibility of early prevention and treatment of acute lung injury by using composite Rhodiolae (CR) in patients with severe pulmonary hypertension during extracorporeal circulation. METHODS: Seventy-six patients with severe pulmonary hypertension screened out by color 2D-Doppler ultrasonography were randomly divided into the treated group (n = 40) and the control group (n = 36). The general treatment for the two groups, including preoperational preparation, operational procedure and conventional drug therapy, was the same. To the treated group, CR was administered 4 g every day (half the dose in children) at 7-10 day before and 5-7 day after the operation. The life signs, pulmonary ventilation parameters, arterial blood gas analysis were monitored and blood levels of TXB2, 6-keto-PGF1 alpha in both groups were determined in the fixed time points. RESULTS: The various parameters in the treated group were all better than those in the control group (P < 0.05 or P < 0.01), the occurrence rate of acute lung injury and its mortality in the treated group were 7.5% (3/40) and 0% (0/3) respectively, while in the control group were 19.4% (7/36) and 43% (3/7) respectively. CONCLUSION: CR has good preventive and treatment effect in treating complicated acute lung injury during extracorporeal circulation (cardiopulmonary bypass) in patients with pulmonary hypertension.