Effects of Subchronic Inhalation of D-D (1,3-Dichloropropene/1,2-Dichloropropane) on Reproduction in Male and Female Rats

Effects of Subchronic Inhalation of D-D (1,3-Dichloropropene/l,2-Dichloropropane) on Reproduction in Male and Female Rats.LINNETT, S. L., CLARK, D. G., BLAIR, D., AND CASSIDY, S. L.(1988). Fundam. Appl. Toxicol. 10, 214-223. The effects of inhaledD-D (1,3-dichloropro-pene/1,2-dichloropropane) on reproductionwere studied in rats of both sexes. The rats inhaled nominalconcentrations of 0, 10, 30, or 90 ppm (v/v) D-D for 6 hr/day,5 days/week for 10 weeks. Treated males of proven fertilitywere paired with untreated virgin females at intervals duringand after exposure. Treated females were paired with untreatedmales immediately after the 10-week exposure period. Variousaspects of reproductive performance and general toxicity wereassessed. Exposure to D-D produced no adverse effects on thelibido, fertility, or morphology of the reproductive tractsof rats of either sex; no treatment-related dominant lethaleffect was observed in male rats. Slight reductions in bodyweight gains and slight increases in liver and kidney weightswere observed in 90 ppm rats of both sexes.