| 盐酸多奈哌齐治疗阿尔茨海默病的临床疗效观察 |
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| 引用本文： | 俞正霞,朱福,席佩丽,胡君,毛旭东,王伟良.盐酸多奈哌齐治疗阿尔茨海默病的临床疗效观察[J].老年医学与保健,2010,16(1):44-45. |
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| 作者姓名： | 俞正霞 朱福 席佩丽 胡君 毛旭东 王伟良 |
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| 作者单位： | 徐汇区中心医院老年科,上海市,200031 |
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| 摘 要： | 目的探讨盐酸多奈哌齐对阿尔茨海默病患者认知功能和行为能力的治疗作用。方法收集徐汇区中心医院阿尔茨海默病患者120例，随机分为治疗组与对照组各60例，治疗组采用盐酸多奈哌齐，对照组不使用盐酸多奈哌齐等防治阿尔茨海默病药物。两组患者分别在治疗前和治疗12w、24w后进行MMSE评分及ADL评分的检查。结果治疗组盐酸多奈哌齐治疗后认知、行为能力均较治疗前有明显改善，治疗12w、24w后，MMSE评分分别提高13．8％和23％，ADL评分分别降低9．6％和18．7％（P〈0．01）。结论盐酸多奈哌齐对阿尔茨海默病患者认知、行为能力有显著改善作用。
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| 关 键 词： | 盐酸多奈哌齐 阿尔茨海默病 认知功能 |
Clinical observation of donepezil in treating Alzheimer's disease |
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| YU Zheng-xia,ZHU Fu,XI Pei-li,HU Jun,MAO Xu-dong,WANG Wei-liang.Clinical observation of donepezil in treating Alzheimer''s disease[J].Geriatrics & Health Care,2010,16(1):44-45. |
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| Authors: | YU Zheng-xia ZHU Fu XI Pei-li HU Jun MAO Xu-dong WANG Wei-liang |
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| Institution: | .(Department of Geriatrics, Xuhui District Central Hospital, Shanghai 200031, China) |
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| Abstract: | Objective To investigate the effect of donepezil in treating patients with Alzheimer＇s disease with respect to cognitive function and behavior. Methods 120 patients with Alzheimer＇s disease were randomized to a donepezil treatment group and a control group without using any medication. MMSE Scale and ADL Scale of the two groups were assessed before and at 12 and 24 weeks after treatment . Results The cognitive function and capability were improved significantly in the treatment group （P〈 0.01） conclusions Donepezil can significantly improve the cognitive function and behaviors of patients with Alzheimer＇s disease. |
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| Keywords: | Donepezil Alzheimer＇s disease Cognitive function |
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