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Effects of substance P on adult rat sensory ganglion neurones in vitro |
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| Authors: | A Dray R D Pinnock |
| Affiliation: | 7. Department of Pharmacology (College of Medicine), The University of Arizona, Health Sciences Center, Tucson, AZ 85724 U.S.A.;1. MRC Neurochemical Pharmacology Unit, Medical Research Council Centre, Medical School, Hills Road Cambridge CB2 2QH U.K. |
| Abstract: | Intracellular recordings were performed in vitro from dorsal root ganglion cell bodies isolated from adult rats. A- and C-type cells were distinguished according to the conduction velocity at their axons. Pressure application of substance P from extracellular electrodes caused a depolarization of some cells. This depolarization was accompanied by changes in membrane resistance. These results suggest that the cell bodies of spinal ganglion cells of adult animals may possess substance P receptors. |
| Keywords: | dorsal root ganglion intracellular recordings in vitro substance P |
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