改良序贯疗法治疗幽门螺杆菌阳性消化性溃疡的临床观察

目的观察由奥美拉唑、胶体次枸橼酸铋钾、阿莫西林克拉维酸钾、左氧氟沙星组成的10日改艮序贯疗法治疗幽门螺杆菌（Hp）阳性消化性渍疡的临床疗效及安全性。方法将经胃镜检查确诊为消化性溃疡且Hp阳性的患者117例随机分为两组，治疗组（59例）前5d口服奥美拉唑20mg，2；L／d，阿莫西林克拉维酸钾457mg，2坎／d，饭前半小时服胶体次枸橼酸铋钾200rng，2；L／d，后5d口服奥美拉唑20mg，2；L／d，左氧氟沙星200mg，2次／d；对照组（58例）口服奥美拉唑20mg，2次／d。阿莫西林克拉维酸钾457mg，2；L／d，饭后服用克拉霉素500mg，2；k／d，疗程10d，疗程结束4周后行13^C-尿素呼气试验检测。结果治疗组3^C尿素呼气试验转阴率为94．9％，对照组转阴率为70．6％，两组Hp转阴率比较差异具有统计学意义（P〈0．05）。结论改艮序贯疗法治疗Hp阳性消化性渍疡具有较高的Hp根除率，安全性好.

The clinical observation of improved sequential therapies for Helicobacter pylori - positive peptic ulcer

Objective To observe the clinical efficacy and safety of ten -days sequential therapy consisted of omeprazole, colloidal bismuth subcitrate potassium, amoxicillin and clavulanate potassium, levofloxacin on Helicobacter pylori （Hp） -positive peptic ulcer. Methods Totally 117 Helicobacter pylofi -infected patients with peptic ulcer diagnosed by gastroscopy were enrolled. The patients were randomized divided into treatment group （59 cases） who received omeprazole 20 rag, 2 times one day, amoxicillin and clavulanate potassium 457 rag, 2 times one day, after meal colloidal bismuth subcitrate potassium 200 mg, 2 times one day, for the first five days, and followed by omeprazole 20 rag, 2 times one day, levofloxacin 200 mg, 2 times one day, for the last five days;the control group （58 cases） treated with omeprazole 20 mg, 2 times one day, amoxicillin and clavulanate potassium 457 rag, 2 times one day, after meals clarithromycin 500 rag, 2 times one day, for ten days, 4 weeks underwent J3C -urea breath test. Resuits The treatment group 13C urea breath test negative rate was 94.9%, negative control group was 70. 6% , compared two groups of Hp negative rate was significant difference （P 〈 0.05）. Conclusions The modified sequential therapy of Hp -positive peptic ulcer with high eradication rates and safe is good.