美金刚治疗帕金森病痴呆的临床观察

目的:观察美金刚治疗帕金森病痴呆的疗效及安全性。方法:将52例帕金森病痴呆患者随机分为治疗组32例,对照组20例。治疗组使用美金刚5mg,对照组行常规治疗,并进行4、12、24周临床简易精神状态量表(MMSE)评价认知功能,UPDRSⅢ评定患者开期的运动功能观察。结果:治疗组治疗4周后,MMSE评分无明显改善,12、24周后MMSE改善明显,差异有统计学意义(P<0.01)。UPDRSⅢ评分:治疗组4、12周后有一定程度改善(P<0.01),而24周后改善不明显。对照组治疗4、12周后MMSE、UPDRSⅢ均无明显改善,而24周后有一定程度改善(P<0.01)。两组均无明显不良反应。结论:美金刚可改善帕金森病患者认知功能,具有安全性,且对运动障碍的改善有一定帮助。

Effect of memantine on dementia in Parkinson's disease

Objective： To evaluate the safety and efficiency of memantine on dementia in Parkinson＇s disease. Methods： A total of 52 cases of Parkinson＇s dementia were randomly divided into treatment group （32 cases）, and control group （20 cases）. The treatment group was treated with 5 mg rnemantine while the control group was treated with conventional therapy, mini-mental state examination （MMSE） and UPDRSⅢ wcreapplied to evaluate patients＇ cognitive ability and motor function 4, 12, and 24 weeks after the treatment. Results： MMSE scores was not significantly improved in the treatment group after 4 weeks of treatment, while 12 and 24 weeks later, there were significant difference （P〈 0.01）. UPDRS Ⅲ scores didn＇t show improvement until 24 weeks of treatment. On the contrary, the control group only showed little progress of MMSE and UPDRS Ⅲ scores after 24 weeks treatment（P〈 0.02）. Conclusions： Memantine can improve both cognitive and motor functions for patients with Parkinson＇s dementia with great security.