保肝汤抗慢性鸭乙型肝炎的实验研究

目的:观察保肝汤体内抗慢性鸭乙型肝炎的作用。方法:采用人工感染鸭乙型肝炎病毒的武汉麻鸭为动物模型,用保肝汤大、小剂量组口服治疗1个月,观察用药前后血清转氨酶(ALT、AST)、血清总胆红素(TBiL)及肝组织HE染色的病理改变,并以阿昔洛韦作阳性对照。结果:保肝汤大剂量组和阿昔洛韦组与模型对照组之间比较血清谷丙转氨酶(ALT)均有显著性差异(P<0.05);病理切片显示,大剂量组的肝细胞点状坏死和碎屑样坏死与模型对照组相比,有显著性差异(P<0.05)。结论:保肝汤连续用药后有一定的抗炎及护肝作用。

Experiment Study on the Therapeutie Effect of Protecting Liver Soup on Chronic Duck Hepatitis

Objective:To study the therapeutie effect of protecting liver Soup on chronic duck hepatitis.Methods:The Wuhan duck hepatitis B model was treated with low and large dosage groups of protecting liver soup for one month.We observed the morphic changements of liver tissue and detected ALT and AST in serums after carrying on experiment.The trial was contrasted with acyclovir.Results:After giving medication with protecting liver soup for one month,the ALT in ducklings’sera were obviously lower than that before treatmcnt,there were remarkable imparities between treatment groups and model contrastive group(P<0.05),Pathology slices show that puntiform necrosis and fragmented necrosis of liver between large dosage groups of protecing liver soup treatment group and model group had remarkable imparities(P<0.05).Conclusions:The study confirms that this traditional medicine have protecting liver effects.