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Adeno-associated Virus Vectors Serotype 2 Induce Prolonged Proliferation of Capsid-Specific CD8+ T Cells in Mice |
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| Authors: | Hua Li Steven Tuyishime Te-Lang Wu Wynetta Giles-Davis Dongming Zhou Weidong Xiao Katherine A High Hildegund CJ Ertl |
| Affiliation: | 1Immunology Program, Wistar Institute, Philadelphia, Pennsylvania, USA;2Department of Cellular and Molecular Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA;3Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA;4Department of Pediatrics, The Children''s Hospital of Philadelphia and Howard Hughes Medical Institute, Philadelphia, Pennsylvania, USA |
| Abstract: | Using adoptive transfer models we determined that an adeno-associated viral vector of serotype 2 (AAV2) induces in mice proliferation of CD8+ T cells that recognize an epitope within the viral capsid. Proliferation to an endogenous epitope within viral protein (VP)3 could be observed for at least 3 weeks while a foreign epitope placed at multiple copies within VP2 elicited CD8+ T cell expansion for at least 10 weeks. These data show that capsid antigens of AAV2 degrade slowly over a period of weeks and during this period provide targets to CD8+ T cells. |
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