47例原发性乳腺癌多药耐药MDR1基因表达及其临床意义

目的]探讨原发性乳腺癌多药耐药MDR1基因的表达及其临床意义.方法]采用荧光定量RT-PCR法检测47例乳腺癌组织及15例正常对照(包括5例乳腺纤维腺瘤、10例癌旁组织)MDR1基因的表达.结果]乳腺癌MDR1基因表达阳性率为46.8%,与病人年龄、肿瘤大小、淋巴结转移与否、ER、PR状况、绝经与否无关.对照组中无MDR1基因表达.结论]乳腺癌MDR1基因的表达可作为乳腺癌化疗耐药的评价指标,能否作为判断预后的独立指标尚需进一步研究.

Expression of MDR1 Gene in 47 Cases with Breast Cancer and its Clinical Significance

To explore the expression of multidrug resistance gene 1(MDR1) and its clinical significance in primary breast cancer. The expressions of MDR1 gene in 47 cases with breast cancer and 15 cases of normal controls (mastofibroma, 5 cases; adjacent breast tissues, 10 cases) were measured by fluoregenic probe quantitative RT-PCR method. The positive rate of MDR1 gene in breast cancer group was 46.8%. The expression of MDR1 was not related to age, tumor size, lymph node involvement, estrogen receptor and progesterone receptor status and menopause. Whereas, no positive case was found in control group. Conclusion] The expression of MDR1 gene in breast cancer maybe serve as an indicator for drug resistance in chemotherapy.