The effect of chronic lithium administration on dopamine metabolism in rat striatum |
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| Authors: | J. E. Hesketh N. M. Nicolaou G. W. Arbuthnott A. K. Wright |
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| Affiliation: | (1) MRC Brain Metabolism Unit, 1, George Square, Edinburgh, UK;(2) Present address: Centre de Neurochimie, 11, rue Humann, Strasbourg, France |
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| Abstract: | Striatal dopamine and its metabolites were studied in rats given lithium chloride in the diet. Results showed an increase in homovanillic acid and 3,4-dihydroxyphenylacetic acid levels but no significant change in dopamine concentration after 3 weeks of lithium administration. There was no change in tyrosine hydroxylase activity after 1, 2, and 3 weeks treatment. The results indicate an increase in the release and turnover of dopamine in the lithium-treated animals. |
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| Keywords: | Lithium treatment Dopamine metabolism Striatum |
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