| 当归补血丸中阿魏酸溶出度测定 |
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| 引用本文： | 付丽佳,王玉华.当归补血丸中阿魏酸溶出度测定[J].中国实验方剂学杂志,2013,19(5):144-146. |
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| 作者姓名： | 付丽佳 王玉华 |
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| 作者单位： | 大庆市油田总局药剂科,黑龙江大庆,163000 |
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| 摘 要： | 目的:对当归补血丸中阿魏酸进行溶出度测定,以控制其内在质量.方法:选择桨法,采用高效液相色谱法(HPLC)测定当归补血丸在不同取样时间点下的溶出液中阿魏酸含量,计算累积溶出率,SAS软件拟合Weibull分布模型,并提取溶出参数.结果:当归补血丸中的阿魏酸在4h内溶出达到95％,溶出曲线符合Weibull分布模型,阿魏酸的溶出参数T50,Td分别为47,69 min.结论:该溶出度测定方法简便易行,准确可靠,可以用于当归补血丸的质量控制.
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| 关 键 词： | 当归补血丸 溶出度 阿魏酸 高效液相色谱法 |
| 收稿时间： | 7/3/2012 12:00:00 AM |
Dissolution Determination of Ferulic Acid in Danggui Buxue Pill |
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| FU Li-jia and WANG Yu-hua.Dissolution Determination of Ferulic Acid in Danggui Buxue Pill[J].China Journal of Experimental Traditional Medical Formulae,2013,19(5):144-146. |
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| Authors: | FU Li-jia and WANG Yu-hua |
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| Institution: | Dept. of Pharmacy, General Hospital Group Oilfield Hospital of Daqing, Daqing 163000, China;Dept. of Pharmacy, General Hospital Group Oilfield Hospital of Daqing, Daqing 163000, China |
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| Abstract: | Objective: Study the dissolution of ferulic acid in Danggui Buxue Pill, in order to control the quality of pill. Method: Paddle method was chosen and the content of ferulic acid of the pill in different sample time was measured by HPLC. At last time, the dissolution percentage was accounted, to fit the Weibull model and get the dissolution parameters of T50 and Td by SAS software. Result: The dissolution percentage of ferulic acid in Danggui Buxue Pill was 95% in four hour of sample time, and the best dissolution model was Weibull model. The T50and Td of ferulic acid were 47min and 69min. Conclusion: The established dissolution method was accuracy, sensitive and simple. It can be used for quality control of Danggui Buxue Pill. |
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| Keywords: | Danggui Buxue Pill dissolution ferulic acid HPLC |
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