Hepatitis B and C virus infection in Polish children with malignancies |
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| Authors: | D. Januszkiewicz J. Wysocki J. Nowak |
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| Affiliation: | (1) Institute of Paediatrics, Academy of Medical Sciences, Poznań, Poland, PL;(2) Institute of Human Genetics, Polish Academy of Sciences Strzeszyńska 32, PL-Poznań 61-489, Poland Tel. and Fax: 0-61-48-233235, PL |
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| Abstract: | ![]()
Infections by hepatotropic viruses belong to the most common complications of chemotherapy in children suffering from neoplastic diseases. The rate of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and the effectiveness of passive immunization against HBV were studied in 285 children; 148/285 with lymphoproliferative diseases and 137/285 with solid tumours. HBV infection was observed in 10.2% children receiving hepatitis B immune globulin as compared to 36.8% without passive immunization against HBV. Anti-HCV antibodies were similar in both groups amounting 38.7% and 32.6% respectively. Conclusion The results show that hepatitis B immune globulin administration is effective and that HCV might become the main cause of hepatitis among immunosuppressed patients in the future. Received: 13 December 1994 / Accepted: 18 October 1996 |
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| Keywords: | Hepatitis B and C virus Malignancies in children Passive immunization against HBV infection |
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