局灶性癫痫患者认知障碍的相关性分析

目的 通过神经心理评估探究局灶性癫痫患者可能产生认知障碍的相关因素.方法 收集2016年3月-2020年1月于天津医科大学总医院门诊及住院的癫痫病患者53例,其中男25例,女28例,平均年龄(23.58±13.24)岁,平均病程(6.49±7.39)年,均符合2017年国际抗癫痫联盟(ILEA)局灶性癫痫的诊断标准,无...

Correlation analysis of cognitive impairment in patients with focal epilepsy

Objective Through neuropsychological assessment,explore the factors that may cause cognitive impairment in patients with focal epilepsy.Methods Collected 53 epilepsy patients in outpatients and inpatients of Tianjin Medical University General Hospital from March 2016 to January 2020,including 25 males and 28 females,with an average age of(23.58±13.24)years old,and the course of disease(6.49±7.39),all met the 2017 ILEA diagnostic criteria for focal epilepsy,and there was no history of progressive brain disease or brain surgery.Carry out relevant cognitive assessments for the enrolled patients,use SPSS statistical software to conduct Spearman correlation analysis on the cognitive functions of the study subjects,and further analyze the related factors of cognition through Logistic regression analysis to clarify the factors related to cognition whether it may be a risk factor for cognitive impairment in patients with focal epilepsy.Results①Spearman correlation analysis showed that the FIQ of patients with focal epilepsy was related to education level,age of onset,seizure pattern,total number of seizures,AEDs and EEG interval discharge side(P<0.05).②Binary Logistic regression analysis shows that among all cognitive-related factors,only the number of AEDs(P=0.003)and EEG interval discharge(P=0.013)are the risk of cognitive impairment in patients with focal epilepsy factor.Conclusion In the clinical treatment of epilepsy,seizures should be actively controlled,but the types of drugs should be minimized.When there are more than 3 kinds of drugs,surgical treatment or other non-surgical treatments can be considered.At the same time,the EEG should be reviewed regularly to understand the changes in epileptiform discharges between episodes.