| 蒙药复方白脉散对脑缺血再灌注大鼠神经损伤的保护作用研究 |
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| 引用本文： | 赵多明,张梓倩,段云霞,张本忠,刘庆山.蒙药复方白脉散对脑缺血再灌注大鼠神经损伤的保护作用研究[J].时珍国医国药,2011,22(9):2066-2068. |
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| 作者姓名： | 赵多明 张梓倩 段云霞 张本忠 刘庆山 |
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| 作者单位： | 1. 兰州大学公共卫生学院卫生毒理研究所,甘肃,兰州,730000
2. 中央民族大学中国少数民族传统医学研究院,北京,100081 |
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| 摘 要： | 目的观察蒙药复方白脉散对大鼠脑缺血再灌注神经损伤的保护作用。方法将健康成年大鼠随机分为3组:假手术组、缺血再灌注模型组、白脉散组。术前灌胃给药7 d,末次给药30 min后,采用改良的线栓法制作大鼠大脑中动脉闭塞再灌注(MCAO/R)模型。苏醒后对其神经功能进行评分;缺血2 h再灌注24 h后观察病灶处病理学变化,测定脑匀浆上清超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量、还原型谷胱甘肽含量、一氧化氮合酶(NOS)活性等。结果与模型组比较,蒙药复方白脉散组病灶处皮层神经元肿胀坏死有所减轻;脑匀浆上清SOD活性和GSH含量明显升高,MDA含量显著降低(P<0.05);T-NOSi、NOSc、NOS活性均明显降低(P<0.05)。结论蒙药复方白脉散对大鼠局灶性脑缺血有明显的保护作用,其机制可能是通过有效的拮抗自由基损伤,提高脑组织抗氧化能力来实现的。
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| 关 键 词： | 蒙药白脉散 脑缺血再灌注损伤 氧化应激 |
Neuroprotective Effect of Mongolian Medicine BaiMai Power on Cerebral Ischemia-reperfusion Injury in Rats |
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| ZHAO Duo-ming,ZHANG Zi-qian,DUAN Yun-xia,ZHANG Ben-zhong,LIU Qing-shan.Neuroprotective Effect of Mongolian Medicine BaiMai Power on Cerebral Ischemia-reperfusion Injury in Rats[J].Lishizhen Medicine and Materia Medica Research,2011,22(9):2066-2068. |
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| Authors: | ZHAO Duo-ming ZHANG Zi-qian DUAN Yun-xia ZHANG Ben-zhong LIU Qing-shan |
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| Institution: | ZHAO Duo-ming1,2,ZHANG Zi-qian2,DUAN Yun-xia2,ZHANG Ben-zhong1,LIU Qing-shan2(1.College of Public Health,Lanzhou University,Lanzhou 730000,China,2.College of Chinese Traditional Minority Medicine,Minzu University of China,Beijing 100081,China) |
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| Abstract: | Objective To investigate the neuroprotective effects of Mondlian medicine BaiMai Power on cerebral ischemia-reperfusion injury in rats. Methods 36 Wistar rats were divided into three groups randomly:sham-operation group,cerebral ischemia-reperfusion injury group,Mongolian medicine BaiMai Power treatment group.Intraluminal thread method was applied to establish the middle cerebral artery occlusion reperfusion model(MCAO/R)in rats.The rats of Mongolian medicine BaiMai Power group were given Mongolian medicine... |
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| Keywords: | Mongolian medicine BaiMai Power Cerebral ischemia-reperfusion injury Oxidative stress |
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