| 维生素E对培养人内皮细胞脂质过氧化损伤的保护作用 |
| |
| 引用本文： | 杨向红,陈铁镇. 维生素E对培养人内皮细胞脂质过氧化损伤的保护作用[J]. 中国医科大学学报, 1992, 0(6) |
| |
| 作者姓名： | 杨向红 陈铁镇 |
| |
| 作者单位： | 中国医科大学基础医学部实验病理学研究室，中国医科大学基础医学部实验病理学研究室 |
| |
| 基金项目： | 国家“七五”科技攻关课題 |
| |
| 摘 要： | 本实验以维生素E作用于培养的人血管内皮细胞,从形态结构和功能方面观察了维生素E对内皮细胞脂质过氧化作用的影响,探讨维生素E抗动脉粥样硬化作用的途径。结果表明:维生素E能抑制内皮细胞的脂质过氧化反应,使脂质过氧化引起的细胞收缩和生物膜系统损伤的程度减轻,使细胞PG_2合成增加。提示维生素E通过防止内皮细胞的氧化性损伤,可能在抗动脉粥样硬化病变形成中起重要作用。
|
| 关 键 词： | 内皮细胞 脂质过氧化 维生素E 动脉粥样硬化 |
PROTECTIVE EFFECT OF VITAMIN E ON CULTURED HUMAN ENDOTHELIAL CELLS INJURED BY LIPID PEROXIDE |
| |
| Yang Xianghong,Chen Tiezhen. PROTECTIVE EFFECT OF VITAMIN E ON CULTURED HUMAN ENDOTHELIAL CELLS INJURED BY LIPID PEROXIDE[J]. Journal of China Medical University, 1992, 0(6) |
| |
| Authors: | Yang Xianghong Chen Tiezhen |
| |
| Affiliation: | Lab. of Experimental Pathology |
| |
| Abstract: | In this study, cultured human endothelial ceils (ECs) were treated with cumene hydroperoxide to stimulate and faciliate lipid peroxidation and the antioxidant effect of vitamin E was observed both morphologically and functionally. The measurement of LPO concentration of cells showed that vitamin E could lower the LPO concentration increased by cumene hydroperoxide, moreo(?) the levels of-6-1 eto-PGE_1 increased and the mo(?)hologic injur(?)e of the cells were lightened.Vitamin E might play an impoitant iole in antiatherocclero(?)is thiough the piotective effect on endethelial cells. |
| |
| Keywords: | endothelial cell lipid perokidation vitamin E athe osclerosis |
| 本文献已被 CNKI 等数据库收录！ |
