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Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations
Authors:Chen Xiaoli  Lingala Shilpa  Khoobyari Shiva  Nolta Jan  Zern Mark A  Wu Jian
Institution:1Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of California, Davis Medical Center, Sacramento, CA 95817, United States;2Stem Cell Program, University of California, Davis Medical Center, Sacramento, CA 95817, United States;3Cancer Center, University of California, Davis Medical Center, Sacramento, CA 95817, United States
Abstract:
Keywords:Abbreviations: ALDH  aldehyde dehydrogenase  APC  allophycocyanin  CPM  cyclopamine  CSCs  cancer stem cells  DAPI  4&prime    6-diamidino-2-phenylindole  EMT  epithelial mesenchymal transition  FACS  fluorescence-activated cell sorting  FITC  fluorescein isothiocyanate  GAPDH  glyceraldehyde 3-phosphate dehydrogenase  HCC  hepatocellular carcinoma  Hh  hedgehog  PCNA  proliferating cell nuclear antigen  TGF-β1  transforming growth factor-β1
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