Atrial Natriuretic Peptide (ANP) in early pregnancy is associated with development of preeclampsia in type 1 diabetes |
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| Authors: | Ringholm Lene Pedersen-Bjergaard Ulrik Thorsteinsson Birger Boomsma Frans Damm Peter Mathiesen Elisabeth R |
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| Affiliation: | aCenter for Pregnant Women with Diabetes, Rigshospitalet, University of Copenhagen, Denmark;bDepartment of Endocrinology, Rigshospitalet, Copenhagen, Denmark;cEndocrinology Section, Department of Cardiology and Endocrinology, Hillerød Hospital, Denmark;dFaculty of Health Sciences, University of Copenhagen, Denmark;eSection of Vascular Pharmacology and Metabolism, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands;fDepartment of Obstetrics, Rigshospitalet, Copenhagen, Denmark |
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| Abstract: | ![]()
The vasoactive markers of cardiac overload Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) are elevated in preeclampsia. This study documents higher ANP concentrations as early as at 9 weeks in type 1 diabetic women subsequently developing preeclampsia suggesting that preeclampsia is associated with cardiovascular changes in early pregnancy. |
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| Keywords: | Abbreviations: ANP, Atrial Natriuretic Peptide BNP, Brain Natriuretic Peptide CI, confidence interval HbA1c, hemoglobin A1c OR, odds ratio SMPG, self-monitored plasma glucose UAE, Urinary Albumin Excretion |
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