| 维生素E琥珀酸酯对人肝癌细胞凋亡和侵袭性 |
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| 引用本文： | 彭林,王志度,吴泽宇.维生素E琥珀酸酯对人肝癌细胞凋亡和侵袭性[J].岭南现代临床外科,2007,7(4):255-256. |
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| 作者姓名： | 彭林 王志度 吴泽宇 |
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| 作者单位： | 广东省人民医院普外三科,广州510080 |
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| 基金项目： | 广东省医学研究基金（A2006019） |
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| 摘 要： | 目的研究维生素E琥珀酸酯（VES）诱导体外培养人肝癌细胞凋亡以及对肝癌细胞侵袭性的抑制作用。方法自2004年至2005年7月,体外培养SMMC7721人肝癌细胞系,在培养液中加入VES共育,用等量的生理盐水作为对照组。培养6、24、48h后采用流式细胞仪检测肝癌细胞的凋亡,小孔趋化试验检测肝癌细胞的体外侵袭性变化。结果在加入VES后肝癌细胞的凋亡率与对照组相比明显增加。在48h加入VES的实验组与对照组相比,肝癌细胞的小孔趋化试验明显受到抑制。结论VES具有体外诱导人肝癌细胞系凋亡以及抑制肝癌细胞体外侵袭性的作用,是潜在的抗肿瘤因子。
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| 关 键 词： | 肝癌 维生素E 凋亡 侵袭 |
| 文章编号： | 1009-976X（2007）04-0255-02 |
| 修稿时间： | 2007-05-30 |
Influence of vitamin E succinate(VES) on the apoptosis and invasion of human hepatocellular carcinoma cell line |
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| PENG Lin. WANG Zhidu, WU Zeyu.Influence of vitamin E succinate(VES) on the apoptosis and invasion of human hepatocellular carcinoma cell line[J].Lingnan Modern Clinics in Surgery,2007,7(4):255-256. |
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| Authors: | PENG Lin WANG Zhidu WU Zeyu |
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| Abstract: | Objective To study the influence of vitamin E succinate(VES)on the apoptosis and invasive ability of human hepatocellular carcinoma cell line.Methods Vitamin E succinate(VES)was mixed in the SMMC7721 cell line culture juice,the same amount of 0.9% Nacl sol was as control group.After 6,24,and 48 hours,the apoptosis and invasion role of the hepatocellular carcinoma cell line was observed by the flow cytometry and microchemotaxis test.Results After VES was added,the apoptosis rate of hepatocellular carcinoma of experimental group was mnch higher than that control group.Comparison between experimental group and control group in the microchemotasis test of hepatocellular carcinoma,the former was inhibited abviously after 48 hours added VES.Conclusion Vitamin E succinate(VES)may induce the apoptosis and inbibit the invasive effect for hepatocellular carcinoma in vitro. |
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| Keywords: | Hepatocellular carcinoma Vitamin E Apoptosis invasion |
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