| Role of the caudate-putamen nucleus in sensory gating in induced tinnitus in rats |
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| 作者姓名： | Meng-Lin Wang Yu Song Jun-Xiu Liu Ya-Li Du Shan Xiong Xin Fan Jiang Wang Zhi-Di Zhang Lan-Qun Mao Fu-Rong Ma |
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| 作者单位： | Department of Otolaryngology Head and Neck Surgery;Beijing National Laboratory for Molecular Sciences |
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| 基金项目： | supported by the National Natural Science Foundation of China,Nos.21790391(to LQM)and 81870727(to FRM). |
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| 摘 要： | Tinnitus can be described as the conscious perception of sound without external stimulation,and it is often accompanied by anxiety,depression,and insomnia.Current clinical treatments for tinnitus are ineffective.Although recent studies have indicated that the caudateputamen nucleus may be a sensory gating area involved in noise elimination in tinnitus,the underlying mechanisms of this disorder are yet to be determined.To investigate the potential role of the caudate-putamen nucleus in experimentally induced tinnitus,we created a rat model of tinnitus induced by intraperitoneal administration of 350 mg/kg sodium salicylate.Our results revealed that the mean spontaneous firing rate of the caudate-putamen nucleus was increased by sodium salicylate treatment,while dopamine levels were decreased.In addition,electrical stimulation of the caudate-putamen nucleus markedly reduced the spontaneous firing rate of neurons in the primary auditory cortex.These findings suggest that the caudate-putamen nucleus plays a sensory gating role in sodium salicylate-induced tinnitus.This study was approved by the Institutional Animal Care and Use Committee of Peking University Health Science Center(approval No.A2010031)on December 6,2017.
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| 关 键 词： | caudate-putamen nucleus deep brain stimulation DOPAMINE primary auditory cortex sodium salicylate SOUND STRIATUM TINNITUS |
Role of the caudate-putamen nucleus in sensory gating in induced tinnitus in rats |
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| Meng-Lin Wang,Yu Song,Jun-Xiu Liu,Ya-Li Du,Shan Xiong,Xin Fan,Jiang Wang,Zhi-Di Zhang,Lan-Qun Mao,Fu-Rong Ma.Role of the caudate-putamen nucleus in sensory gating in induced tinnitus in rats[J].Neural Regeneration Research,2021(11). |
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| Abstract: | Tinnitus can be described as the conscious perception of sound without external stimulation, and it is often accompanied by anxiety, depression, and insomnia. Current clinical treatments for tinnitus are ineffective. Although recent studies have indicated that the caudateputamen nucleus may be a sensory gating area involved in noise elimination in tinnitus, the underlying mechanisms of this disorder are yet to be determined. To investigate the potential role of the caudate-putamen nucleus in experimentally induced tinnitus, we created a rat model of tinnitus induced by intraperitoneal administration of 350 mg/kg sodium salicylate. Our results revealed that the mean spontaneous firing rate of the caudate-putamen nucleus was increased by sodium salicylate treatment, while dopamine levels were decreased. In addition, electrical stimulation of the caudate-putamen nucleus markedly reduced the spontaneous firing rate of neurons in the primary auditory cortex. These findings suggest that the caudate-putamen nucleus plays a sensory gating role in sodium salicylate-induced tinnitus. This study was approved by the Institutional Animal Care and Use Committee of Peking University Health Science Center(approval No. A2010031) on December 6, 2017. |
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