Upregulation of miR-370 contributes to the progression of gastric carcinoma via suppression of FOXO1 |
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| Authors: | Conghai Fan Sheng Liu Yupeng Zhao Youqun Han Longqiu Yang Guorong Tao Qing Li Lei Zhang |
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| Affiliation: | 1. XuZhou Children''s Hospital, 18, Sudi North Road, Xuzhou, Jiangsu Province 221006, PR China;2. Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai 200120, PR China;3. Department of Anesthesiology, Jinan Central Hospital, Shandong University School of Medicine, Jinan 250013, PR China;4. Anesthesiology Department, The First Hospital of Shijiazhuang City, 36 Fanxi Road, Chang’an District, Shijiazhuang 050011, PR China;5. Department of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China;6. Department of Anesthesiology, Jiangsu Provincial Hospital of Integrated Chinese Traditional and Western Medicine, 100, Shizi Street, Hongshan Road, Nanjing 210028, PR China;g Department of Anesthesiology, The Ninth People''s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, PR China |
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| Abstract: | ![]()
FOXO1 is downregulated in a number of cancers. However, the underlying mechanisms are poorly understood. In this study, we report that the expression of miR-370 was upregulated in gastric cancer cell lines and gastric cancer tissues. Overexpression of miR-370 in gastric cancer cells promoted the cell proliferation and anchorage-independent growth, while silencing of miR-370 showed opposite effects. miR-370-induced proliferation was correlated with the downregulation of cyclin-dependent kinase inhibitors, p27Kip1 and p21Cip1, and the upregulation of the cell cycle regulator cyclin D1. Furthermore, we identified that FOXO1 is the functional target of miR-370. Restored expression of FOXO1 together with miR-370 strongly abrogated miR-370-induced cell proliferation. Taken together, our results revealed a novel mechanism of FOXO1 suppression mediated by miR-370 in gastric cancer. |
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| Keywords: | MicroRNA370 Cycle progression Proliferation FOXO1 Gastric cancer |
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