| CyclinD1和p27蛋白在膀胱移行细胞癌中的表达 |
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| 引用本文： | 方艺,吴志平. CyclinD1和p27蛋白在膀胱移行细胞癌中的表达[J]. 遵义医学院学报, 2005, 28(5): 421-422 |
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| 作者姓名： | 方艺 吴志平 |
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| 作者单位： | 1. 贵阳医学院,病理教研室,贵州,贵阳,550002
2. 贵阳医学院,附属医院泌尿外科,贵州,贵阳,550002 |
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| 摘 要： | 目的探讨膀胱移行细胞癌中cyclinD1和p27蛋白的表达及其意义.方法采用免疫组化技术检测48例膀胱癌组织中cyclinD1与p27蛋白的表达.结果cyclinD1及p27表达在膀胱移行细胞癌和正常组织之间各有统计学差异,cycliD1和p27与膀胱肿瘤分期、分级相关.cyclinD1与p27蛋白呈反方向表达.结论cyclnD1与p27有助于评估膀胱移行细胞癌的生物学行动.
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| 关 键 词： | p27蛋白 膀胱肿瘤 免疫组织化学 |
| 文章编号： | 1000-2715（2005）05-0421-02 |
| 收稿时间： | 2005-09-18 |
| 修稿时间： | 2005-09-18 |
The expression of cyclinD1 and p27 in transitional cell carcinoma of bladder |
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| FANG Yi,WU Zhi-ping. The expression of cyclinD1 and p27 in transitional cell carcinoma of bladder[J]. Acta Academiae Medicine Zunyi, 2005, 28(5): 421-422 |
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| Authors: | FANG Yi WU Zhi-ping |
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| Affiliation: | Department of pathology, Guiyang Medical College, Guiyang Guichou 550002, China |
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| Abstract: | Objective To investigate the expression and significance of cyclinD1 and p27 in transitional cell carcinoma(TCC).Methods cyclinD1 and p27 expression were examined by immunohistochemical technique in 48 case of TCC.Results The expression of cyclinD1 and p27 protein was significantly different between TCC and normal tissues.The expression rate of cyclinD1 and p27 was correlating with TCC stage.There was a highly significant in verse correlation between the expression of cyclinD1 and p27.Conclusions CyclinD1 and p27 can evaluate the biological behaviour of TCC. |
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| Keywords: | cyclinD1 |
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