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| 聚腺苷二磷酸核糖聚合酶抑制剂在神经保护方面的研究进展 | |
| 引用本文： | 张文婷,姜凤超. 聚腺苷二磷酸核糖聚合酶抑制剂在神经保护方面的研究进展[J]. 中国药物化学杂志, 2007, 17(2): 115-121 |
| 作者姓名： | 张文婷 姜凤超 |
| 作者单位： | 华中科技大学,同济医学院药学院,湖北,武汉,430030 |
| 摘 要： | 作者对聚腺苷二磷酸核糖聚合酶[poly（ADP—ribose）polymerase，PARP]的结构亚型和生物学功能做了简要介绍。归纳了近几年PARP抑制剂在神经保护方面的研究成果。并从结构分类的角度探讨了部分具有应用前景的化合物的构效关系。 |
| 关 键 词： | 神经保护 聚腺苷二磷酸核糖聚合酶抑制剂 构效关系 |
| 文章编号： | 1005-0108（2007）02-0115-07 |
| 收稿时间： | 2006-07-03 |
| 修稿时间： | 2006-07-03 |
Research progress of PARP inhibitors on neuro-protection |
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| ZHANG Wen-ting,JIANG Feng-chao. Research progress of PARP inhibitors on neuro-protection[J]. Chinese Journal of Medicinal Chemistry, 2007, 17(2): 115-121 | |
| Authors: | ZHANG Wen-ting JIANG Feng-chao |
| Affiliation: | School of Pharmacy, Tongji Medical College of Huazhong Science and Techology University, Wuhan 430030, China |
| Abstract: | The poly(ADP-ribose)polymerase(PARP),a nuclear enzyme relative to DNA repair,is a mediator of cell death by ATP depletion.Thus the PARP inhibitor was considered as a novel neuro-protectant.A study about structure and biological activity of PARP was introduced in this review,and emphasis was placed on both the neuro-protective function and the structureactivity relationship of the PARP inhibitors reported in recent years. |
| Keywords: | neuro-protection PARP inhibitor structure-activity relationship |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |