| 负荷量曲美他嗪对冠心病合并原发性高血压患者内皮功能的影响 |
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| 引用本文： | 侯聪聪,李拥军,张辉,杨蓉,王梅,王亚玲.负荷量曲美他嗪对冠心病合并原发性高血压患者内皮功能的影响[J].临床荟萃,2011,26(2):110-112,116. |
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| 作者姓名： | 侯聪聪 李拥军 张辉 杨蓉 王梅 王亚玲 |
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| 作者单位： | 1. 解放军第二五二医院,心内科,河北,保定,071000
2. 河北医科大学第二医院,心内科,河北,石家庄,050000 |
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| 摘 要： | 目的观察曲美他嗪对冠心病合并原发性高血压患者血管内皮功能,指导临床用药。方法入选60例无糖尿病及高脂血症病史的冠心病合并原发性高血压患者,患者入院第3日病情平稳后检测血浆一氧化氮（NO）水平,并行肱动脉超声以检测血流介导的血管扩张变化率（flow-mediated dilation,FMD）。随后立刻顿服负荷量盐酸曲美他嗪片60 mg,并抽肘静脉血2 ml用以测定血浆NO水平。记录服药前后各项数据,并对数据行配对t检验。结果顿服负荷量曲美他嗪2小时后患者血浆NO水平明显高于服药前血浆NO水平,（49.33±9.84）μmol/L vs（48.15±11.35）μmol/L（P〈0.05）。顿服负荷量曲美他嗪2小时后患者FMD值明显高于服药前FMD值,（12.77±9.17）%vs（10.99±8.73）%（P〈0.05）。结论患者顿服负荷量曲美他嗪后血浆NO水平显著高于服药前,说明曲美他嗪对内皮细胞具有保护作用;患者顿服负荷量曲美他嗪后肱动脉FMD值显著高于于服药前,说明曲美他嗪能够改善血管内皮依赖性舒张功能;患者顿服负荷量曲美他嗪后未见不良反应。
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| 关 键 词： | 冠状动脉疾病 高血压 内皮 血管 曲美他嗪 一氧化氮 血管舒张 |
Load amount of trimetazidine's influence on endothelial function in patients with coronary heart disease and hypertension |
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| HOU Cong-cong,LI Yong-jun,ZHANG Hui,YANG Rong,WANG Mei,WANG Ya-ling.Load amount of trimetazidine's influence on endothelial function in patients with coronary heart disease and hypertension[J].Clinical Focus,2011,26(2):110-112,116. |
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| Authors: | HOU Cong-cong LI Yong-jun ZHANG Hui YANG Rong WANG Mei WANG Ya-ling |
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| Institution: | HOU Cong-cong,LI Yong-jun,ZHANG Hui,YANG Rong,WANG Mei,WANG Ya-ling Department of Cardiology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China |
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| Abstract: | Objective To investigate the influence of trimetazidine on endothelial function in patients with coronary heart disease(CHD) and essential hypertension for clinical treatment.Methods 60 patients with CHD associated with essential hypertension were enrolled in this study.None of them had history of diabetes mellitus or hyperlipidemia.Plasma nitric oxide(NO) levels and flow-mediated dilation(FMD) rates were detected on the third day of hospitalization.Then the enrolled patients were given trimetazidine hydroc... |
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| Keywords: | coronary disease hypertension endothelium vascular trimetazidine nitric oxide vasodilation |
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