| 晚期非小细胞肺癌维持治疗的研究进展 |
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| 引用本文： | 程婷婷,杨谨.晚期非小细胞肺癌维持治疗的研究进展[J].中华肿瘤防治杂志,2011,18(20):1651-1655. |
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| 作者姓名： | 程婷婷 杨谨 |
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| 作者单位： | 西安交通大学医学院第一附属医院肿瘤内科,陕西西安,710061 |
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| 摘 要： | 目的:总结维持治疗在晚期非小细胞肺癌中的研究进展,探讨维持治疗的意义。方法:应用PubMed和CNKI期刊全文数据库检索系统,以"NSCLC maintenancetherapy及非小细胞肺癌,维持治疗"为关键词,共检索到2001-2011年相关文献284篇,纳入分析25篇。结果:维持治疗是近年来为延长晚期NSCLC患者生存期并提高其生存质量而出现的新的治疗观点,目前已有多项临床试验证实标准一线化疗结束使疾病获得控制后,继续给予维持治疗可以显著延长患者的无疾病进展生存期(progression-free survival,PFS),部分药物可以显著延长总生存(overall survival,OS),患者耐受良好。结论:维持治疗可以使晚期NSCLC患者获益,但是其最终疗效和患者的病理类型、EGFR突变状况、体力状况和对药物的耐受情况密切相关,结合患者的实际情况,进行个体化治疗,是NSCLC患者未来治疗的方向。
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| 关 键 词： | 癌 非小细胞肺/药物疗法 治疗 综述文献 |
Maintenance therapy in advanced non-small cell lung cancer |
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| CHENG Ting-ting,YANG Jin.Maintenance therapy in advanced non-small cell lung cancer[J].Chinese Journal of Cancer Prevention and Treatment,2011,18(20):1651-1655. |
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| Authors: | CHENG Ting-ting YANG Jin |
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| Institution: | CHENG Ting-ting,YANG Jin Department of Medical Oncology,First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,P.R.China |
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| Abstract: | OBJECTIVE: To summarize the advances of maintenance therapy in NSCLC,and discuss the significance of this therapeutic method.METHODS: The full text database of PubMed and CNKI were searched,and the wordsNSCLC,maintenance therapy were used as .Totally 284 related articles were retrieved between the year of 2001 and 2011 in all,then 25 were analyzed.RESULTS: Maintenance therapy emerged as a new viewpoint in these years in order to prolong the overall survival and to improve quality of life for patients with a... |
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| Keywords: | carcinoma non-small cell lung/drug therapy therapy review literature |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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