| 神经胶质瘤的表观遗传学机制 |
| |
| 引用本文： | 王启琼,李银,杨学习. 神经胶质瘤的表观遗传学机制[J]. 分子诊断与治疗杂志, 2011, 3(5): 351-355 |
| |
| 作者姓名： | 王启琼 李银 杨学习 |
| |
| 作者单位： | 1. 南方医科大学第一临床医学院,广东,广州510515
2. 南方医科大学生物技术学院,广东,广州510515 |
| |
| 基金项目： | 南方医科大学课外科研学术活动 |
| |
| 摘 要： | 神经胶质瘤是颅内最常见的一种恶性肿瘤,它的发生、发展与表观遗传修饰密切相关.本文着重介绍了近年来神经胶质瘤发生、发展过程中DNA甲基化异常、miRNA表达异常、组蛋白修饰异常三种主要的表观遗传修饰方式的研究进展.由于表观遗传修饰引起的改变可以通过药物逆转,本文进而探讨了基于表观遗传修饰机制的潜在药物治疗神经胶质瘤的前景...
|
| 关 键 词： | 神经胶质瘤 表观遗传学 DNA甲基化 miRNA 组蛋白修饰 |
Glioma and epigenetic |
| |
| WANG Qiqiong,LI Yin,YANG Xuexi. Glioma and epigenetic[J]. Journal of Molecular Diagnosis and Therapy, 2011, 3(5): 351-355 |
| |
| Authors: | WANG Qiqiong LI Yin YANG Xuexi |
| |
| Affiliation: | 1.The First Affiliated Hospital of Southern Medical University,Guangzhou,Guangdong 510515,China;2.School of Biotechnology,Southern Medical University,Guangdong,Guangzhou 510515,China) |
| |
| Abstract: | Glioma is one of the most common intracranial malignant tumor.Its occurrence and development are closely relevant to epigenetic modification.There were three main epigenetic modification patterns：DNA methylation abnormality,miRNA expression abnormality and histone modification abnormality during the occurrence and development of glioma.Potential drugs for glioma may reverse epigenetic modification mechanism. |
| |
| Keywords: | Glioma Epigenetic DNA methylation miRNA Histone modification |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
