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| 替吉奥胶囊联合三维适形放疗治疗中晚期食管癌的临床观察 | |
| 引用本文： | 袁昕,童建东,殷旭东,薛金俊,汪瑞. 替吉奥胶囊联合三维适形放疗治疗中晚期食管癌的临床观察[J]. 中华肿瘤防治杂志, 2011, 18(20): 1644-1645,1648 |
| 作者姓名： | 袁昕 童建东 殷旭东 薛金俊 汪瑞 |
| 作者单位： | 扬州市第一人民医院肿瘤科,江苏扬州,225000 |
| 摘 要： | 观察替吉奥胶囊联合三维适形放疗治疗中晚期食管癌的近期疗效和毒副反应。58例中晚期食管癌患者随机分成两组,替吉奥胶囊联合三维适形放疗(联合治疗组)32例,单纯放疗组26例,三维适形放疗分割剂量为1.8Gy/次,5次/周,总量50.4Gy/28次,联合治疗组:替吉奥胶囊自放疗第1天开始,按体表面积<1.2m2,40mg,2次/d,1.2～1.5m2,50mg,2次/d,>1.5m2,60mg,2次/d,与放疗同步,服4周,休2周,直至放疗结束。结果联合治疗组CR 5例,PR 19例,总有效率75.0%,单纯放疗组CR 2例,PR 10例,总有效率为46.2%,两组相比有统计学意义,P=0.007。在毒副反应方面,两组总体耐受良好,无严重不良事件发生。初步研究结果提示,替吉奥胶囊联合三维适形放疗治疗中晚期食管癌是一种安全有效的治疗方法。 |
| 关 键 词： | 食管肿瘤/药物疗法 食管肿瘤/放射疗法 综合疗法 放射疗法,适形 |
TS-1 combined with three-dimensional conformal radiotherapy for treatment of advanced esophageal cancer |
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| YUAN Xin,TONG Jian-dong,YIN Xu-dong,XUE Jin-jun,WANG Rui. TS-1 combined with three-dimensional conformal radiotherapy for treatment of advanced esophageal cancer[J]. Chinese Journal of Cancer Prevention and Treatment, 2011, 18(20): 1644-1645,1648 | |
| Authors: | YUAN Xin TONG Jian-dong YIN Xu-dong XUE Jin-jun WANG Rui |
| Affiliation: | YUAN Xin,TONG Jian-dong,YIN Xu-dong,XUE Jin-jun,WANG Rui Department of Oncology,First Hospital of Yangzhou,Yangzhou 225000,P.R.China |
| Abstract: | The objective of this study was to evaluate the efficacy and toxicity of TS-1 combined with three-dimensional conformal radiotherapy(3D-CRT) in treatment of advanced esophageal cancer.Fifty-eight patients with advanced esophageal cancer were divided randomly into groups of two: Ts-1 combined with three-dimensional conformal radiotherapy(combined treatment group,32 cases) and single radiotherapy group(26 cases).The fractionated dose of 3D-CRT was 1.8 Gy/f / 5f/w.The total dose was 50.4 Gy/28 f.Combined treat... |
| Keywords: | esophageal neoplasms/drug therapy esophageal neoplasms/radiotherapy combined modality therapy radiotherapy conformal |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |