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三种实验室检测方法对梅毒诊断的临床意义分析
引用本文:刘意,魏红娟,任翊,黄晓婕. 三种实验室检测方法对梅毒诊断的临床意义分析[J]. 中国艾滋病性病, 2006, 12(6): 541-542
作者姓名:刘意  魏红娟  任翊  黄晓婕
作者单位:北京佑安医院,性病艾滋病临床诊疗中心,北京,100069
摘    要:
目的检验三种梅毒实验室检测方法的梅毒阳性检出率,分析各检测指标间的相互关系,探讨其临床意义。方法抽取性病门诊就诊者的静脉血,用梅毒酶联免疫吸附试验(ELISA)检测梅毒抗体,同时用梅毒螺旋体明胶凝集试验(TPPA)检测同一份血清,二种方法均为阳性者用荧光梅毒螺旋体抗体吸收法(FTA-ABS)检测及免疫印迹法(WB)确认,对试验数据进行统计分析和检查。结果在所有784名性病门诊就诊者中,ELISA检测梅毒抗体阳性者306人,阳性率39.03%;TPPA法检测梅毒抗体阳性为297人,阳性率为37.88%;经FTA-ABS检测确证阳性299人,阳性率为38.14%;最终WB结果与FTA-ABS检测一致。结论为了提高梅毒的检出率及正确性,对高度疑似梅毒的患者,应同时进行两种抗体的检查。

关 键 词:梅毒  酶联免疫吸附试验  梅毒螺旋体明胶凝集试验  荧光梅毒螺旋体抗体吸收法  免疫印迹试验
文章编号:1672-5662(2006)06-0541-02
收稿时间:2006-03-07
修稿时间:2006-04-18

Clinical significance of three types of Treponema Pallidium antibody tests for the diagnosis of syphilis
LIU Yi, WUI Hong-juan , REN Yi ,et al.. Clinical significance of three types of Treponema Pallidium antibody tests for the diagnosis of syphilis[J]. Chinese JOurnal of Aids & STD, 2006, 12(6): 541-542
Authors:LIU Yi   WUI Hong-juan    REN Yi   et al.
Affiliation:Center for STDs /AIDS Clinical Therapy and Diagnosis, Beijing You An Hospital. Bering 100069, China
Abstract:
Objective To analyze the positive rate of three types of specific antibody tests for Treponema pallidum and evaluate their clinical significance.Methods Serum samples of 784 visitors to STD clinics were tested by ELISA and FTAABS,and the positive samples by these two tests were retested by TPPA and Western blot.The data were analyzed by SPSS.Results The positive rate of 784 clinical samples was 39.03%(306/784)by ELISA and 37.88(297/784)by TPPA.In the confirmation test 299(38.14%)samples were positive by FTA-ABS,and of these 299 samples only 2 turned out negative by Western Blot.Conclusion To improve the specificity and sensitivity rate for syphilis diagnosis,two antibody tests should be applied simultaneously.
Keywords:Syphilis  ELISA  TPPA  FTA-ABS  Western blot
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