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| 吡格列酮对实验性兔主动脉粥样硬化的预防作用 | |
| 引用本文： | 张爱娟,张爱元,王赛,季祥武.吡格列酮对实验性兔主动脉粥样硬化的预防作用[J].实用中西医结合临床,2011,11(6):1-3. |
| 作者姓名： | 张爱娟 张爱元 王赛 季祥武 |
| 作者单位： | 1. 山东省潍坊市脑科医院 潍坊261021 2. 山东省潍坊市人民医院 潍坊261000 3. 山东省东营市胜利油田中心医院 东营257000 |
| 摘 要： | 目的:探讨预防性应用吡格列酮(Piog)对血脂和动脉粥样硬化(AS)斑块的影响。方法:24只新西兰白兔随机分为四组,I组:正常对照组6只,II组:高胆固醇饮食(Hi-chol)组6只,III组:Hi-chol加高剂量Piog组6只,IV组:Hi-chol加低剂量Piog组6只,喂养8周后处死。于实验终点取兔血清测定血脂;取兔主动脉,观察血管AS斑块及脂质条纹形成情况;免疫组化法测定主动脉血管内皮金属蛋白酶-9(MMP-9)。结果:(1)血脂:Hi-chol成功诱发高脂血症(高TC、TG、LDL-C,HDL-C下降未达显著水平),预防应用高、低剂量Piog明显降低TG,P<0.001。(2)主动脉AS程度:Hi-chol组AS最明显,高、低剂量Piog明显改善主动脉AS情况。(3)主动脉弓血管内壁免疫组化:Hi-chol组、Hi-chol加高低剂量Piog组MMP-9阳性面积比(阳性染色面积/斑块总面积)与正常对照组比较明显升高(P<0.001),高剂量Piog组与单纯Hi-chol组比较,明显降低其表达(P<0.05)。结论:在新西兰兔中,高脂饮食成功诱发高脂血症和动脉粥样硬化,而预防性服用吡格列酮可一定程度上降低TG水平,抑制粥样斑块形成,高剂量吡格列酮降低主动脉粥样斑块内MMP-9表达。 |
| 关 键 词： | 吡格列酮 噻唑烷二酮 动脉粥样硬化 |
Effects of Pioglitazone on Prevention of Atherosclerosis in Experimental Rabbits |
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| Zhang Ai-juan,Zhang Ai-yuan,Wang Sai.Effects of Pioglitazone on Prevention of Atherosclerosis in Experimental Rabbits[J].Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine,2011,11(6):1-3. | |
| Authors: | Zhang Ai-juan Zhang Ai-yuan Wang Sai |
| Institution: | Zhang Ai-juan,Zhang Ai-yuan,Wang Sai |
| Abstract: | Objective:To observe the preventive effects of pioglitazone on experiental atherosclerotic rabbits. Methods:24 Healthy WHHL(Watanabe Heritable Hyperlipidemic) rabbits were randomly divided into 4 groups(n=6):I normal control group, II high-cholesterol diet (Hi-chol) group, III hi-chol plus high dose pioglitazone (piog) group, IV Hi-chol plus low dose piog group.All animals were feeding for 8 weeks and sacrificed, taking rabbits blood to measure lipids.Observe rabbit arterial atherosclerosis (AS). Expression... |
| Keywords: | Pioglitazone Thiazolidinedions Atherosclerosis |
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