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| 钾通道开放剂烟酰胺对肺动脉高压血浆内皮素1影响的临床观察 | |
| 引用本文： | 周义乾,李金兰,张素荣.钾通道开放剂烟酰胺对肺动脉高压血浆内皮素1影响的临床观察[J].中国综合临床,2008,24(4). |
| 作者姓名： | 周义乾 李金兰 张素荣 |
| 作者单位： | 1. 新乡医学院第一附属医院结核科,河南省卫辉市,453100 2. 新乡医学院第一附属医院呼吸科,河南省卫辉市,453100 3. 新乡医学院第一附属医院心内科,河南省卫辉市,453100 |
| 基金项目： | 河南省科技厅科技攻关项目 |
| 摘 要： | 目的 探讨钾通道开放剂烟酰胺对肺动脉高压患者血浆内皮素的影响.方法 入选66例缺氧性肺动脉高压患者,随机分为烟酰胺治疗组(治疗组)和常规治疗组(对照组),每组33例,测定2组肺动脉高压患者治疗前后血浆内皮素1变化.结果 治疗组治疗后较治疗前血浆内皮素1明显降低(P＜0.01).对照组治疗前后自身比较,血浆内皮素1无明显变化(P＞0.05);治疗组与对照组治疗前后的差值比较有统计学意义(P＜0.01).结论 烟酰胺可保护内皮细胞,减少内皮素1的分泌和释放,对缺氧性肺动脉高压有治疗作用. |
| 关 键 词： | 烟酰胺 肺动脉高压 内皮素1 |
Influence of Nictinamide on endotheline in patients with pulmonary arterial hypertension |
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| ZHOU Yi-qian,LI Jin-lan,ZHANG Su-rong.Influence of Nictinamide on endotheline in patients with pulmonary arterial hypertension[J].Clinical Medicine of China,2008,24(4). | |
| Authors: | ZHOU Yi-qian LI Jin-lan ZHANG Su-rong |
| Abstract: | Objective To study the influence of Nictinamide on the endotheline(ET-1)in patienta with pulmonary arterial hypertension(PAH).Methods 66 cases of PAH were divided randomly into two groups (n=33for each):the Nictinamide treatment group and the control group.The changes of endotheline were compared before and after treatment.Results After treatment serum endotheline was significantly lower in the treatment group(P＜0.01),but there was no difference in the control group before and aftertreatment(P＞0.05).The significant difference was observed between treatment group and control group(P＜0.01).Conclusion Nictinamide will reduce the level of endothellne and confers some degree therapeutic and preventive value for PAH. |
| Keywords: | Nicfinamide Pulmonary arterial hypertension Endotheline 1 |
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