血清白蛋白、前白蛋白与霍奇金淋巴瘤患者近期疗效关系的临床观察#br# #br#

目的探讨血清白蛋白（ALB）、前白蛋白（PA）与霍奇金淋巴瘤（HL）患者近期疗效的关系。 方法收集2010年1月至2016年7月在解放军307医院确诊初治的103例HL患者的临床资料，并进行回顾性分析。根据治疗前ALB和PA水平进行分组，分析其对HL近期疗效的影响。 结果2～6个周期化疗后，103例HL患者中达完全缓解（CR）60 例（583％），部分缓解（PR）37 例（359％），总有效率（RR）为942％。ALB＜35 g／L组患者中CR 7例（200％），ALB≥35 g／L组患者中CR 53例（779％）；PA＜200 mg／L组患者中CR 23例（383％），PA≥200 mg／L组患者中CR 37例（860％）。与ALB≥35 g／L组比较，ALB＜35 g／L组患者多伴有B症状、分期晚、节外侵犯、IPS评分高及CR率低（P＜005）； 与PA≥200 mg／L组比较， PA＜200 mg／L组患者多伴有B症状、分期晚、节外侵犯、IPS评分高、淋巴结侵犯区域≥3及CR率低（P＜005）。Logistic 多因素分析显示仅ALB是HL治疗获CR的独立因素。 结论治疗前ALB和PA与近期疗效CR相关，对HL的近期疗效有意义。

Clinical significance of serum albumin and prealbumin in the short term efficacy of hodgkin lymphoma

ObjectiveTo investigate the clinical significance of serum albumin （ALB） and prealbumin （PA） in the short term efficacy of hodgkins lymphoma （HL）. MethodsThe clinical data of 103 patients with HL who were diagnosed as initial diagnosis at 307 Hospital from January 2010 to July 2016 were collected and analyzed retrospectively. Based on the ALB and PA levels before treatment， the short term efficacy of HL was analyzed. ResultsAmong the 103 patients with HL， complete remission（CR） was achieved in 60 cases（583％）， partial remission（PR） in 37 cases （359％）， and the total effective rate was 942％. Among the patients with ALB＜35 g／L， 7 cases （200％） achieved CR. Among the patients with ALB≥35 g／L， 53 cases （779％） achieved CR. Among the patients with PA＜200 mg／L， 23 cases （383％） achieved CR. Among the patients with PA≥200 mg／L， 37cases （860％） achieved CR. Compared with ALB＜35 g／L group， the patients with ALB＜35 g／L often had B symptoms， advanced stage， extranodal involvement， high IPS score and low CR rate （P＜005）. Compared with PA≥200 mg／L group， the patients with PA＜200 mg／L often accompanied by B symptoms， extranodal involvement， high IPS score， lymph nodal sites≥3 and low CR rate （P＜005）. Multivariate analysis showed that ALB alone was an independent factor for CR in HL. ConclusionPre treatment ALB and PA are associated with CR of HL， and have a significant effect on the short term efficacy of HL.