| MPTP对鼠肝脂质过氧化作用的影响 |
| |
| 引用本文： | 陈生弟,周孝达,钱可久.MPTP对鼠肝脂质过氧化作用的影响[J].上海交通大学学报(医学版),1990(3). |
| |
| 作者姓名： | 陈生弟 周孝达 钱可久 |
| |
| 作者单位： | 上海第二医科大学附属仁济医院神经内科
(陈生弟，周孝达)，上海第二医科大学附属仁济医院神经内科(钱可久) |
| |
| 摘 要： | 本文报道给C57小鼠腹腔注射不同剂量1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)后,发现组3(MPTP35 mg/kg,每天一次,共7天)鼠肝匀浆、线粒体和微粒体的膜丙二醛含量明显增加,与对照组相比分别增加70.5%,67%和51.4%(P<0.01),而组1(MPTP 35mg/kg,每4小时一次,共3次)和组2(MPTP35mg/kg,每天一次,共4天)鼠肝丙二醛含量与对照组相近。结果表明MPTP有明显地促进鼠肝脂质过氧化的作用,并与其剂量有关。
|
| 关 键 词： | 甲基-苯基-四氢吡啶 C57小鼠肝 脂质过氧化 |
The Effects of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) on Lipid Peroxidation of Mouse Liver |
| |
| Chen Shengdi,et al.The Effects of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) on Lipid Peroxidation of Mouse Liver[J].Journal of Shanghai Jiaotong University:Medical Science,1990(3). |
| |
| Authors: | Chen Shengdi |
| |
| Institution: | Chen Shengdi,et al Department of Neurology,Renji Hospital,Shanghai Second Medical University,Shanghai |
| |
| Abstract: | The administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) 35 mg/kg daily for 7 days markedly increased hepatic malonaldehyde (MDA) level in C57 mice. Tne increase was 70.5% in hepatic homogenates, 67% in mitochondria and 51.4% in microsomes (P<0.01). However, the use of MPTP 35 mg/kg daily for 4 days or 3 injections of 35 mg/kg at 4 h intervals in a single day did not show the same effect. This result suggests that MPTP can significantly accentuate lipid peroxidation of mouse liver, and that the effcct is dose-dependent. |
| |
| Keywords: | 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine C57 mouse liver lipid peroxidation |
| 本文献已被 CNKI 等数据库收录！ |
|
