鼻咽癌癌细胞群体的PCNA免疫组化研究

应用免疫组化技术对４７例石蜡包埋组织的鼻咽癌癌细胞群体的增殖细胞核抗原（ＰＣＮＡ）进行分析。结果显示：角化性癌细胞和梭形癌细胞、不规则形癌细胞至泡状核癌细胞群体，其ＰＣＮＡ阳性率依次递增，表明鼻咽癌存在增殖潜能异质性的癌细胞群体，泡状核癌细胞增殖能力最高，不规则形癌细胞次之。作者认为不同形态的癌细胞群体在组织中的比例不但决定鼻咽癌的组织类型，而且其增殖潜能异质性将影响鼻咽癌治疗和临床预后。

PCNA immunohistochemical study of the cancer cell populations in nasopharyngeal carcinoma

The proliferating cell nuclear antigen(PCNA)of 47 cases of nasopharngeal carcinoma NPC were studied immunohistochemically.The results showed that the PCNA positive rate was increased progressively in the order of keratinizing cancer,fusiform cancer,irregularly shaped cancer and cancer cells with vesicular nuclei,indicating that the cancer cell populations with proliferative activity heterogeneity(PAH)existed in NPC,of which the cancer cells with vesicular nuclei had the highest proliferative activity,suggesting that the cancer cell populations with PAH were an important factor to influence not only the changes of the histological type of NPC but also the clinical treatment and prognosis.