帕金森病患者非运动症状特点及其影响因素

目的 研究帕金森病(PD)患者的非运动症状(NMS)的分布状况和影响因素.方法 收集2007年1月至2009年3月北京医院门诊就诊的111例PD患者及46名健康对照,对其进行NMS问卷调查,比较两组各项NMS的分布,并结合临床特征等因素分析NMS发生的主要影响因素.结果 PD组的NMS-T(NMS总数)明显高于对照组.平均每例PD患者有12项NMS,并且随病情的加重而增多.UPDRS-Ⅲ(统一帕金森病评定量表第三部分)、左旋多巴剂量、年龄与NMS.T正相关,对NMS-T的决定作用占26.9%.左旋多巴剂量、Hoehn.Yahr分级、UPDRS-Ⅲ、NMS.T与UPDRS-II(统一帕金森病评定量表第二部分)正相关,对UPDRS-Ⅱ的决定作用占70.3%.结论 PD患者的NMS发生率明显高于对照组;NMS分布于各期PD患者,且随着病情的加重及年龄的增长而增多;NMS对PD患者的生活质量有很大影响.

Characteristics and influencing factors of non-motor symptoms in Parkinson's disease

Objective To assess the characteristics and influencing factors of non-motor symptoms (NMS) in patients with Parkinson's disease(PD). Methods A total of 111 patients with PD and 46 healthy controls (HC) matched with age, gender, education status and occupation were investigated by NMS questionnaire. They were all outpatients of Beijing hospital. The distribution of NMS items was analyzed between two groups. And their clinical characteristics were also collected to assess the dominant influencing factors for the prevalence of NMS. Results There was significant difference in the prevalence of NMS between two groups (P<0. 01). Each PD patient had an average of 12 NMS throughout the disease stages and the number of NMS was increasing with the degree of disease severity. UPDRS-Ⅲ (united Parkinson's disease rating scale) , daily dose of levodopa and age showed a positive correlation with NMS-T ( NMS Total) and they accounted for 26.9% of the variance of NMS-T. Daily dose of levodopa, Hoehn-Yahr stage, UPDRS-Ⅲ and NMS-T showed a positive correlation with UPDRS- Ⅱ and they accounted for 70. 3% variance of UPDRS- Ⅱ. Conclusion NMS are more commonly seen in PD patients than in controls. NMS is present throughout every stages of PD and its number increases with the degree of disease severity and age. The quality of life is impaired significantly by NMS in PD patients.