| HPLC法测定金甲排石胶囊中厚朴酚与和厚朴酚的含量 |
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| 引用本文： | 陈喜生,胡滨湘.HPLC法测定金甲排石胶囊中厚朴酚与和厚朴酚的含量[J].中国现代药物应用,2009,3(23):15-17. |
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| 作者姓名： | 陈喜生 胡滨湘 |
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| 作者单位： | 1. 湖南省娄底市药品检验所,417000
2. 娄底市中心医院 |
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| 摘 要： | 目的建立测定金甲排石胶囊中厚朴酚与和厚朴酚含量的HPLC测定方法。方法采用Shim-pack VP-ODS C18柱，甲醇-水（78：22）为流动相，检测波长为294nm，流速1．0ml／min。结果厚朴酚在0．56μg～1．68μg范围内与峰面积呈良好线性关系，r=0．9999，平均加样回收率为99．40％，RSD为1．4％（n=6）；和厚朴酚在0．116μg～0．347μg范围内与峰面积呈良好线性关系，r=0．9999，平均加样回收率为99．26％，RSD为1．6％（n=6）。结论该方法简便、准确，专属性强，重现性好，可用于金甲排石胶囊的质量控制。
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| 关 键 词： | 金甲排石胶囊 厚朴酚 和厚朴酚 HPLC |
Determination of Magnolol and Honokiol in Jinjiapaishi Capsules by HPLC |
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| CHEN Xi-sheng,HU Bin-xiang.Determination of Magnolol and Honokiol in Jinjiapaishi Capsules by HPLC[J].Chinese Journal of Modern Drug Application,2009,3(23):15-17. |
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| Authors: | CHEN Xi-sheng HU Bin-xiang |
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| Institution: | CHEN Xi-sheng , HU Bin-xiang.( The Institute for Drug Control of Loudi, Hunan Loudi d17000, China) |
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| Abstract: | Objective To establish an HPLC for determination of magnolol and honokiol in Jinjiapaishi Capsules. Methods A Shim-pack VP-ODS C18 column was used. The mobile phase was methanol-water（78： 22） , the detecting wavelength was at 294 nm, the flow rate was 1.0 ml/min. Results The linear range of magnolol was within 0. 56 μg - 1.68 μg,r =0. 9999,the average sample recovery was 99. 40% with RSD of 1.4% （ n = 6 ） ; the linear range of honokiol was within 0. 116 μg - 0. 347 μg, r = 0. 9999, the average sample recovery was 99. 26% with RSD of 1.6% （n = 6）. Conclusion This method has good repeatability,flexibility and high sensitivity. It can be used for quality control of Jinjiapaishi Capsules. |
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| Keywords: | HPLC |
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