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| 基质金属蛋白酶-9与创面修复 | |
| 引用本文： | 龚加庆,李雅,方驰华. 基质金属蛋白酶-9与创面修复[J]. 中国烧伤创疡杂志, 2003, 15(3): 242-246 |
| 作者姓名： | 龚加庆 李雅 方驰华 |
| 作者单位： | 1. 成都军区总医院全军普外中心,四川,成都,610083 2. 第一军医大学珠江医院普通外科,广东,广州,510082 |
| 基金项目： | 全军医学科研“十五”计划面上项目资助 (0 1MA134) |
| 摘 要： | MMP-9是金属蛋白酶家族中分子量最大的酶，它受许多细胞因子的调节。目前认为细胞外基质的降解在很大程度上取决金属蛋白酶与其抑制剂的平衡。MMP-9可作用较广泛的底物，在创面修复中起到重要作用，但在各种创面如急性创面、感染创面和慢性创面中的含量及相应作用有所不同，并且从某种程度上说MMP-．9在创面渗液中的含量对创面的愈合趋势有一定的预测作用。对MMP-9的深入研究必将有助于攻克创面愈合中的种种难题。 |
| 关 键 词： | MMP-9 创面修复 展望 |
| 文章编号： | 1001-0726(2003)03-0242-05 |
| 修稿时间： | 2002-11-21 |
Matrix metallo-proteinase-9 and wound repair |
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| GONG Jia-qing ,LI Ya ,FANG Chi-hua . Matrix metallo-proteinase-9 and wound repair[J]. The Chinese Journal of Burns Wounds & Surface Ulcers, 2003, 15(3): 242-246 | |
| Authors: | GONG Jia-qing LI Ya FANG Chi-hua |
| Affiliation: | GONG Jia-qing 1,LI Ya 1,FANG Chi-hua 2,1. The Center of General Surgery,General Hospital of Chengdu Military Region,Chengdu,Sichuan Province 610083,China, 2. Dept of General Surgery,Zhujiang Hospital,The 1 st Military Medical University,Guangzhou,Guangdong Province 510082,China |
| Abstract: | Matrix metallo-proteinase-9 is an enzyme having the largest molecular weight in the family. It is regulated by many cellular factors. A balance between matrix metallo-proteinase and its inhibitors is very important for the degradation of the cellular-matrix. Since matrix metallo-proteinase-9 can act on many substrates, it is important for wound repair. The content of matrix metallo-proteinase-9 in the acute and chronic and infected wounds are not the same, so the effects of matrix metallo-proteinase-9 are different. To some extent, the content of matrix metallo-proteinase-9 in the wound fluid may forecast the healing tendency of the wound. Further research on matrix metallo-proteinase-9 will help resolve many problems about wound healing. |
| Keywords: | matrix metallo-proteinase-9 wound repair prospect |
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