舍格伦综合征亚临床型

目的进一步观察舍格伦综合征（Ｓｊ¨ｏｇｒｅｎ＇ｓｓｙｎｄｒｏｍｅ，ＳＳ）亚临床型的各种表现及治疗。方法对２４例ＳＳ亚临床型患者长期临床观察，并行实验室、腮腺造影及肌内注射胸腺肽治疗。结果２４例患者在出现口干、眼干之前有腮腺反复肿胀史２～１７年（平均７年），均误诊为“慢性化脓性腮腺炎”或“腮腺腺炎”，追踪观察均为典型的ＳＳ。２４例中有１０例患者同时伴有脉管炎或出血性紫癜，占４０％，脉管系统受累较普遍。腮腺造影以末梢导管扩张伴主导管扩张及边缘粗糙为主，１２／２４例，占７０％。肌内注射胸腺肽能明显减少腮腺反复肿胀发作频率。结论提出ＳＳ亚临床型对澄清慢性腮腺炎症命名及分类上的混乱有实际意义，并对早期诊治ＳＳ有指导意义。肌内注射胸腺肽能减少肿胀发作频率。

Subclinical Sj?gren''s syndrome]

OBJECTIVE: To investigate various manifestations and treatment of subclinical Sj?gren's syndrome (SS). METHODS: A long term clinical, laboratory and sialographic observations were performed in 24 patients with subclinical SS. Injectin of thymosin intramusularly was used to treat the patients and clinical effect of this treatment was evaluated. RESULTS: All of 24 cases had experienced recurrent parotid swellings (RPS) for 2-17 years (mean 7 years) before dry mouth and dry eyes occurred and all of them were misdiagnosed as chronic suppurative parotitis or sialadenitis. Follow-up showed that all of these patients developed SS. Vasculitis was found in 8 cases, purpura in 2 cases. The vascular involvement was relatively common in subclinical SS. Main sialographic findings was sialectasis of terminal ducts with irregular dilation of main duct. Frequency of RPS was markedly decreased in the patients treated with thymosin. CONCLUSION: The proposal of subclinical SS has theoretical value for understanding the entity and reclassification of chronic suppurative parotitis, and has guide value for diagnosis and treatment of SS in the early stage. Injection of thymosin is considered an effective therapy to reduce RPS in subclinical SS.