|
|||||
|
|
| Effects of intracellular application of CsCL on action potential and contractio, | |
| 引用本文： | CUI Yi, Derek A TERRAR(University Department of Pharmacology,Mansfield jRoad,Oxford OX13QT,UK). Effects of intracellular application of CsCL on action potential and contractio,[J]. 中国药理学与毒理学杂志, 1995, 0(1) |
| 作者姓名： | CUI Yi Derek A TERRAR(University Department of Pharmacology Mansfield jRoad Oxford OX13QT UK) |
| 作者单位： | University Department of Pharmacology，Mansfield jRoad，Oxford OX13QT，UK |
| 摘 要： | ＥｆｆｅｃｔｓｏｆｉｎｔｒａｃｅｌｌｕｌａｒａｐｐｌｉｃａｔｉｏｎｏｆＣｓＣｌｏｎａｃｔｉｏｎＰｏｔｅｎｔｉａｌａｎｄｃｏｎｔｒａｃｔｉｏｎｏｆｉｓｏｌａｔｅｄｇｕｉｎｅａ－ｐｉｇｖｅｎｔｒｉｃｕｌａｒｃｅｌｌｓＣＵＩＹｉ；ＤｅｒｅｋＡＴＥＲＲＡＲ（... |
Effects of intracellular application of CsCl on action Potentialand contraction of isolated guinea-pig ventricular cells |
|
| CUI Yi, Derek A TERRAR. Effects of intracellular application of CsCl on action Potentialand contraction of isolated guinea-pig ventricular cells[J]. Chinese Journal of Pharmacology and Toxicology, 1995, 0(1) | |
| Authors: | CUI Yi Derek A TERRAR |
| Abstract: | Effects of intracellular application of CsClon action potential duration and contraction were investi-gated in isolated guineapig ventricular cells. CsCl caused aprolongation in action potential duration after it was injectedinto the cells and simultaneously decreased contraction. In thepresence ofcompound Ⅱ, which is a highly specific delayed re-ctifier K+ channel blocker, the change caused by CsCl in ac-tion potentials, but not in contraction, was abolished. In thepresence of ryanodine which blocks the Ca2+ release channelsin sarcoplasmic reticulum, CsCl did not show any effect oncontraction. These results suggested that blocking sarcoplasmicreticulum K+ channels by CsCl could reduce the Ca2+ releasefrom the sarcoplasmic reticulum. |
| Keywords: | myocardium sarcoplasmicreticulum ion channels K contraction cesium |
| 本文献已被 CNKI 等数据库收录！ | |