胰肾联合移植后应用连续性肾脏替代治疗1例

目的：探讨连续性肾脏替代治疗在胰肾联合移植后急性肾功能衰竭及多器官功能衰竭中应用的疗效。 方法：1例胰肾联合移植患者在术后出现移植肾急性肾功能衰竭、移植胰急性胰腺炎、肺感染、十二指肠空肠吻合口出血、腹膜炎等并发症，在积极的抗排斥、抗感染、抑制胰酶、止血、营养支持治疗的同时进行床边连续性肾脏替代治疗治疗，应用百特BM25机器进行连续性静脉-静脉血液滤过治疗，共治疗22 d。 结果：连续性肾脏替代治疗治疗期间生命体征、血流动力学稳定。并迅速控制了肺水肿，维持了水电解质酸碱平衡稳定。经过22 d共计180 h的连续性肾脏替代治疗治疗，患者移植胰肾功能逐渐恢复，患者住院40 d痊愈出院。 结论：连续性肾脏替代治疗在胰肾联合移植后急性肾功能衰竭及多器官功能衰竭的治疗中发挥了重要作用，是胰肾联合移植后良好的肾脏支持方式。

Application of continuous renal replacement therapy in simultaneous pancreas-kidney transplantation: One case report

OBJECTIVE: To study the effect of continuous renal replacement therapy on acute renal failure and multiple organ dysfunction syndrome following simultaneous pancreas-kidney transplantation. METHODS: A patient was complicated with acute renal failure, severe acute pancreatitis, lung infection, bleeding in anastomosis between duodenum and jejunum, and peritonitis following simultaneous pancreas-kidney transplantation. He was treated with immunosuppressor, antibiotics, amylopsin inhibitor, haemostatic and alimentation; at the same time, he was treated with continuous renal replacement therapy for 22 days. The Baxter system was used for continuous venovenous hemofiltration. RESULTS: The vital signs and hemodynamic indicators were stable during continuous renal replacement therapy. Pulmonary edema was well controlled, and acid-base equilibrium of water electrolyte was maintained. The function of vital organs was stable and graft function was normal following continuous renal replacement therapy for 22 days. He was completely cured and out of hospital on day 40. CONCLUSION: Continuous renal replacement therapy plays an important role in treating acute renal failure and multiple organ dysfunction syndrome following simultaneous pancreas-kidney transplantation. Thus, it is a well kidney support for ultaneous pancreas-kidney transplantation.