5-HTTLPR variants not associated with autistic spectrum disorders |
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| Authors: | N. Zhong L. Ye W. Ju J. Tsiouris I. Cohen W. T. Brown |
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| Affiliation: | (1) Department of Human Genetics, New York State Institute for Basic Research, 1050 Forest Hill Road, Staten Island, NY 10314, USA Tel: +1-718-494-5242; Fax: +1-718-494–1026 e-mail: omrddzhong@aol.com, IS;(2) George A. Jervis Clinic, New York State Institute for Basic Research, Staten Island, NY 10314, USA, IS |
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| Abstract: | To determine whether there is an association of polymorphic variants of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) and autistic spectrum disorders, we analyzed the 5-HTTLPR genotypes of 72 autistic subjects, 11 fragile X syndrome patients with autistic behavior, 43 normal subjects, and 49 fragile X syndrome non-autistic subjects. The distribution frequency of 5-HTTLPR long allele (L) and the short allele (S) variants showed no differences between subjects. Our findings do not support the hypothesis that polymorphic 5-HTTLPR variants are a susceptibility factor for autistic disorders. Received: August 5, 1998 / Accepted: December 22, 1998 / Published online: March 11, 1999 |
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| Keywords: | Autism Serotonin transporter Genotypes Polymorphism Fragile X syndrome |
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