| 葡萄糖透析液与腹膜纤维化研究进展 |
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| 引用本文： | 李建飞,刘伏友.葡萄糖透析液与腹膜纤维化研究进展[J].国际病理科学与临床杂志,2006,26(4):21-358. |
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| 作者姓名： | 李建飞 刘伏友 |
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| 作者单位： | 中南大学湘雅二医院肾内科,长沙,410011;中南大学湘雅二医院肾内科,长沙,410011 |
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| 摘 要： | 湘雅二医院肾内科，长沙 410011）［摘要］ 使用葡萄糖透析液进行腹膜透析透是治疗终末期肾脏病的有效措施之一。但近年来大量临床研究发现,透析液中葡萄糖对腹膜的结构和功能有重要影响，导致腹膜纤维化，超滤失败,最终放弃腹膜透析。了解透析液中葡萄糖对腹膜的影响及潜在的治疗策略具有十分重要的意义。
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| 关 键 词： | 葡萄糖 葡萄糖降解产物 糖基化终末产物 腹膜纤维化 |
| 文章编号： | 1673-2588(2006)04-0355-04 |
| 收稿时间： | 2006-3-10 |
| 修稿时间： | 2006年3月10日 |
Advance of glucose-based dialysate and peritoneal fibrosis |
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| LI Jian-fei,LIU Fu-you.Advance of glucose-based dialysate and peritoneal fibrosis[J].Journal of International Pathology and Clinical Medicine,2006,26(4):21-358. |
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| Authors: | LI Jian-fei LIU Fu-you |
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| Institution: | Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China |
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| Abstract: | Peritoneal dialysis(PD) using glucose-based dialysate is one of the effective treatment for patients with end-stage renal disease.But many clinical investigations show that exposure of the peritoneal membrane to high glucose concentrations contributes to both structural and functional changes in the dialyzed peritoneal membrane.In the end,patients drop out from PD due to peritoneal fibrosisand ultrafiltration failure over time on dialysis.So it is very important to know adverse effects of glucose in PD solutions and potential therapeutic interventions. |
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| Keywords: | glucose glucose degradation products advanced glycation end products peritoneal fibrosis |
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